Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 3/20 | 0.53 |
| ▸ | MEN1 | O00255 | 2/20 | 0.49 |
| ▸ | HDAC1 | Q13547 | 3/20 | 0.46 |
| ▸ | HDAC4 | P56524 | 2/20 | 0.46 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.46 |
| ▸ | PARP1 | P09874 | 1/20 | 0.45 |
| ▸ | CASP3 | P42574 | 1/20 | 0.43 |
| ▸ | PREP | P48147 | 1/20 | 0.42 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.41 |
| ▸ | USP2 | O75604 | 1/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.40 |
| ▸ | DHPS | P49366 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28638917 | 0.90 | KMT2A (0.47) | KMT2AMEN1TDP1 | |
| SCHEMBL30604612 | 0.90 | KMT2A (0.47) | KMT2AMEN1TDP1 | |
| SCHEMBL30604606 | 0.90 | KMT2A (0.45) | KMT2AMEN1HDAC1HDAC4HDAC6 | |
| SCHEMBL28656930 | 0.90 | KMT2A (0.45) | KMT2AMEN1HDAC1HDAC4HDAC6 | |
| SCHEMBL28639031 | 0.90 | KMT2A (0.57) | KMT2AMEN1HDAC1HDAC4HDAC6 | |
| SCHEMBL28652153 | 0.90 | KMT2A (0.53) | KMT2AMEN1HDAC1HDAC4HDAC6 | |
| SCHEMBL30604571 | 0.90 | KMT2A (0.53) | KMT2AMEN1HDAC1HDAC4HDAC6 | |
| SCHEMBL30604607 | 0.89 | KMT2A (0.51) | KMT2AMEN1MAPTDHPS | |
| SCHEMBL28636452 | 0.89 | KMT2A (0.51) | KMT2AMEN1MAPTDHPS | |
| SCHEMBL28647745 | 0.88 | HDAC1 (0.47) | KMT2AMEN1HDAC1HDAC4HDAC6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-113493438-B | Tetrahydroisoquinoline compounds | 南京再明医药有限公司 | 2023-10-20 | — | — | CN | disclosed |
| CN-113493438-A | Tetrahydroisoquinoline compounds | 江苏先声药业有限公司 | 2021-10-12 | — | — | CN | disclosed |