SCHEMBL28633723

SCHEMBL28633723

N=C(N)N[C@@]1(n2ccc(N)nc2=O)O[C@H](COP(=O)(O)OP(=O)(O)O)[C@@H](O)[C@H]1O

nearest known ligand 0.55

Predicted protein targets (top 5)

geneUniProtsupporting neighboursconfidence
POLG P54098 1/20 0.44
P2RY2 P41231 10/20 0.44
POLB P06746 1/20 0.42
P2RY6 Q15077 9/20 0.41
P2RY4 P51582 6/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL28643489 0.82 LMNA (0.46) POLB
SCHEMBL26102705 0.81 POLG (0.51) POLGP2RY2POLBP2RY6P2RY4
SCHEMBL18394211 0.81 P2RY2 (0.51) POLGP2RY2POLBP2RY6P2RY4
Guanidine SCHEMBL28645150 0.80 P2RY2 (0.42) POLGP2RY2POLBP2RY6P2RY4
SCHEMBL10903450 0.80 POLG (0.45) POLGP2RY2POLBP2RY6P2RY4
SCHEMBL30697338 0.79 P2RY2 (0.51) POLGP2RY2P2RY6P2RY4
SCHEMBL30140872 0.79 POLG (0.49) POLGP2RY2POLBP2RY6P2RY4
SCHEMBL4257981 0.79 POLG (0.46) POLGP2RY2POLBP2RY6P2RY4
SCHEMBL17632199 0.79 POLG (0.46) POLGP2RY2POLBP2RY6P2RY4
SCHEMBL31337304 0.78 POLG (0.47) POLGP2RY2POLBP2RY6P2RY4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-113423877-A Mutant tRNAs for codon expansion 中外制药株式会社 2021-09-21 CN disclosed