Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 7/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 3/20 | 0.38 |
| ▸ | GAA | P10253 | 2/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.37 |
| ▸ | NPC1 | O15118 | 4/20 | 0.37 |
| ▸ | RAB9A | P51151 | 4/20 | 0.37 |
| ▸ | MAPT | P10636 | 3/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | ATM | Q13315 | 1/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 3/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5648948 | 0.73 | SMN1; SMN2 (0.41) | HPGDALDH1A1NPSR1MEN1KMT2A | |
| SCHEMBL5649629 | 0.73 | ALDH1A1 (0.45) | HPGDALDH1A1NPSR1MEN1KMT2A | |
| SCHEMBL29014071 | 0.71 | NPC1 (0.53) | HPGDALDH1A1NPSR1MEN1KMT2A | |
| SCHEMBL28751123 | 0.67 | ALDH1A1 (0.41) | HPGDALDH1A1NPSR1MEN1KMT2A | |
| SCHEMBL5648255 | 0.67 | ALDH1A1 (0.41) | HPGDALDH1A1NPSR1MEN1KMT2A | |
| SCHEMBL5650999 | 0.67 | ALDH1A1 (0.41) | HPGDALDH1A1NPSR1MEN1KMT2A | |
| SCHEMBL5645448 | 0.66 | ALDH1A1 (0.40) | HPGDALDH1A1NPSR1MEN1KMT2A | |
| SCHEMBL5650293 | 0.65 | ALDH1A1 (0.42) | HPGDALDH1A1NPSR1MEN1KMT2A | |
| SCHEMBL28650726 | 0.65 | ALDH1A1 (0.39) | HPGDALDH1A1NPSR1MEN1KMT2A | |
| SCHEMBL28995960 | 0.65 | SMN1; SMN2 (0.44) | HPGDALDH1A1NPSR1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-113490666-A | Substituted pyrazolo [1,5-A ] pyridine compounds as inhibitors of FGFR tyrosine kinases | 奥瑞生物药品公司 | 2021-10-08 | — | — | CN | disclosed |
| CN-113474337-A | 7- ((3, 5-dimethoxyphenyl) amino) quinoxaline derivatives as FGFR inhibitors for the treatment of cancer | 奥瑞生物药品公司 | 2021-10-01 | — | — | CN | disclosed |