Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Propylene Glycol. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.50 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 2/20 | 0.32 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5904489 | 0.83 | HSD17B10 (0.44) | TDP1MAPK1HSD17B10 | |
| E968 SCHEMBL20515145 | 0.82 | LMNA (0.36) | TDP1 | |
| Glycerin SCHEMBL3824470 | 0.82 | LMNA (0.47) | — | |
| SCHEMBL24835632 | 0.81 | HSD17B10 (0.43) | TDP1MAPK1HSD17B10 | |
| Propylene Glycol SCHEMBL694327 | 0.81 | TDP1 (0.67) | TDP1MAPK1TSHR | |
| SCHEMBL15930 | 0.81 | ALDH1A1 (0.39) | MAPK1TSHR | |
| SCHEMBL3096124 | 0.81 | ALDH1A1 (0.39) | MAPK1TSHR | |
| SCHEMBL28101808 | 0.80 | ALDH1A1 (0.30) | — | |
| Lactic Acid SCHEMBL28444410 | 0.79 | TP53 (0.48) | TDP1MAPK1 | |
| SCHEMBL21457612 | 0.79 | DPP4 (0.31) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115300611-B | Hyaluronic acid-conoid polypeptide conjugate and application thereof in preparation of skin products | 山东大学 | 2024-05-28 | — | — | CN | disclosed |
| CN-115353555-B | Quaternized chitosan oligosaccharide-mu-conotoxin conjugate as well as preparation method and application thereof | 山东大学 | 2024-04-30 | — | — | CN | disclosed |
| CN-117398453-A | Polyglutamic acid-superoxide dismutase compound and preparation method and application thereof | 山东大学 | 2024-01-16 | — | — | CN | disclosed |
| CN-117379534-A | Conus toxin carboxymethyl chitosan oligosaccharide nanoparticle as well as preparation method and application thereof | 山东大学 | 2024-01-12 | — | — | CN | disclosed |
| CN-115737832-A | Hyaluronic acid-dolastatin conjugate and application thereof in tumor resistance | 山东大学 | 2023-03-07 | — | — | CN | disclosed |
| CN-113402633-B | Hyaluronic acid-superoxide dismutase conjugate and application thereof in skin care products | 山东大学 | 2022-04-05 | — | — | CN | disclosed |
| CN-113402633-A | Hyaluronic acid-superoxide dismutase conjugate and application thereof in skin care products | 山东大学 | 2021-09-17 | — | — | CN | disclosed |