Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Bicarbonate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.58 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.58 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.51 |
| ▸ | MAPT | P10636 | 4/20 | 0.51 |
| ▸ | MEN1 | O00255 | 3/20 | 0.51 |
| ▸ | LMNA | P02545 | 1/20 | 0.51 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.47 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.47 |
| ▸ | HTT | P42858 | 2/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.46 |
| ▸ | TP53 | P04637 | 2/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | THRB | P10828 | 1/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.45 |
| ▸ | GPR35 | Q9HC97 | 2/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28252591 | 0.90 | ALDH1A1 (0.69) | ALDH1A1HIF1AKMT2AMAPTMEN1 | |
| SCHEMBL29379039 | 0.90 | ALDH1A1 (0.69) | ALDH1A1HIF1AKMT2AMAPTMEN1 | |
| SCHEMBL85604 | 0.90 | ALDH1A1 (0.69) | ALDH1A1HIF1AKMT2AMAPTMEN1 | |
| Hydrochloric Acid SCHEMBL30306150 | 0.88 | ALDH1A1 (0.67) | ALDH1A1HIF1AKMT2AMAPTMEN1 | |
| SCHEMBL27621933 | 0.85 | ALDH1A1 (0.58) | ALDH1A1HIF1AKMT2AMAPTMEN1 | |
| SCHEMBL7624344 | 0.82 | ALDH1A1 (0.51) | ALDH1A1HIF1AKMT2AMAPTMEN1 | |
| SCHEMBL25837924 | 0.79 | ALDH1A1 (0.64) | ALDH1A1HIF1AKMT2AMAPTMEN1 | |
| SCHEMBL77925 | 0.79 | ALDH1A1 (0.64) | ALDH1A1HIF1AKMT2AMAPTMEN1 | |
| SCHEMBL1654660 | 0.79 | ALDH1A1 (0.59) | ALDH1A1HIF1AKMT2AMAPTMEN1 | |
| SCHEMBL195145 | 0.79 | ALDH1A1 (0.59) | ALDH1A1HIF1AKMT2AMAPTMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-113453681-A | Substituted 3- ((3-aminophenyl) amino) piperidine-2, 6-dione compounds, compositions thereof, and methods of treatment using the same | 细胞基因公司 | 2021-09-28 | — | — | CN | disclosed |