Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.49 |
| ▸ | MEN1 | O00255 | 2/20 | 0.49 |
| ▸ | THRB | P10828 | 2/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.49 |
| ▸ | LMNA | P02545 | 1/20 | 0.49 |
| ▸ | POLB | P06746 | 1/20 | 0.49 |
| ▸ | RECQL | P46063 | 1/20 | 0.49 |
| ▸ | IDO1 | P14902 | 7/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.47 |
| ▸ | FTO | Q9C0B1 | 1/20 | 0.46 |
| ▸ | HPGDS | O60760 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | USP2 | O75604 | 1/20 | 0.39 |
| ▸ | PKM | P14618 | 1/20 | 0.39 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | FNTA | P49354 | 2/20 | 0.39 |
| ▸ | FNTB | P49356 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2462914 | 0.78 | MEN1 (0.60) | MAPTMEN1THRBMAPK1KMT2A | |
| SCHEMBL28640384 | 0.77 | FTO (0.38) | IDO1CYP3A4FTOHPGDSFNTA | |
| SCHEMBL21857697 | 0.74 | IDO1 (0.54) | MAPTMEN1THRBMAPK1KMT2A | |
| SCHEMBL28636872 | 0.73 | FTO (0.44) | KMT2AALDH1A1IDO1CYP3A4FTO | |
| SCHEMBL28926573 | 0.73 | FTO (0.44) | KMT2AALDH1A1IDO1CYP3A4FTO | |
| SCHEMBL980179 | 0.73 | IDO1 (0.46) | MAPK1IDO1CYP3A4HPGDSCSF1R | |
| SCHEMBL6316181 | 0.71 | ALDH1A1 (0.54) | MAPTMEN1THRBMAPK1KMT2A | |
| SCHEMBL2417930 | 0.69 | IDO1 (0.45) | IDO1CYP3A4HPGDSCSF1RCYP2E1 | |
| SCHEMBL4849742 | 0.69 | ALDH1A1 (0.51) | MAPTMEN1THRBMAPK1KMT2A | |
| SCHEMBL21857476 | 0.68 | KMT2A (0.59) | MAPTMEN1THRBKMT2APOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-113396145-A | PFKFB3 inhibitors and uses thereof | 盖罗发现有限责任公司 | 2021-09-14 | — | — | CN | disclosed |