SCHEMBL28637733

SCHEMBL28637733

O=C1C=CC(=O)N1c1cc2ccccc2n1-c1ccccc1

nearest known ligand 0.50

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
MGLL Q99685 10/20 0.50
ALDH1A1 P00352 3/20 0.50
TSHR P16473 1/20 0.50
HSP90AA1 P07900 4/20 0.46
FAAH O00519 5/20 0.45
ATM Q13315 2/20 0.45
PKM P14618 1/20 0.45
HTT P42858 1/20 0.45
NOTUM Q6P988 1/20 0.40
PLA2G10 O15496 1/20 0.38
TLR9 Q9NR96 1/20 0.38
KDM4E B2RXH2 2/20 0.38
GAA P10253 1/20 0.38
HPGD P15428 1/20 0.38
CYP19A1 P11511 1/20 0.38
L3MBTL1 Q9Y468 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6417750 0.77 HSP90AA1 (0.46) MGLLALDH1A1HSP90AA1FAAHATM
SCHEMBL23539385 0.76 HSP90AA1 (0.36) ALDH1A1TSHRHSP90AA1ATMNOTUM
SCHEMBL28123905 0.71 ALDH1A1 (0.59) ALDH1A1TSHRATMHTTNOTUM
SCHEMBL12451390 0.70 ALDH1A1 (0.46) ALDH1A1TSHRATMNOTUMKDM4E
SCHEMBL6991905 0.69 NOTUM (0.46) MGLLALDH1A1TSHRHSP90AA1FAAH
SCHEMBL28723434 0.69 ALDH1A1 (0.53) ALDH1A1TSHRHTTNOTUMKDM4E
Benzene SCHEMBL28088808 0.69 MGLL (1.00) MGLLALDH1A1HSP90AA1FAAHATM
SCHEMBL18713 0.69 MGLL (1.00) MGLLALDH1A1HSP90AA1FAAHATM
SCHEMBL8920586 0.69 MGLL (1.00) MGLLALDH1A1HSP90AA1FAAHATM
SCHEMBL11766114 0.68 ALDH1A1 (0.51) ALDH1A1TSHRNOTUMPLA2G10KDM4E

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-113563307-B Method for synthesizing alpha-cyclic amine maleimide hybrid 河南师范大学 2022-05-17 CN claimed
CN-113563307-A Method for synthesizing alpha-cyclic amine maleimide hybrid 河南师范大学 2021-10-29 CN claimed
CN-113563307-B Method for synthesizing alpha-cyclic amine maleimide hybrid 河南师范大学 2022-05-17 CN disclosed
CN-113563307-A Method for synthesizing alpha-cyclic amine maleimide hybrid 河南师范大学 2021-10-29 CN disclosed