Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOTUM | Q6P988 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.40 |
| ▸ | DAO | P14920 | 2/20 | 0.38 |
| ▸ | TLR9 | Q9NR96 | 1/20 | 0.35 |
| ▸ | MGLL | Q99685 | 2/20 | 0.34 |
| ▸ | CA12 | O43570 | 1/20 | 0.34 |
| ▸ | BRD4 | O60885 | 1/20 | 0.34 |
| ▸ | BRPF1 | P55201 | 1/20 | 0.34 |
| ▸ | CA9 | Q16790 | 1/20 | 0.34 |
| ▸ | KAT2B | Q92831 | 1/20 | 0.34 |
| ▸ | BRD9 | Q9H8M2 | 1/20 | 0.34 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | KLK7 | P49862 | 1/20 | 0.34 |
| ▸ | FAAH | O00519 | 1/20 | 0.33 |
| ▸ | PLA2G10 | O15496 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6675287 | 0.74 | NOTUM (0.49) | NOTUMALDH1A1TSHRDAOCA12 | |
| SCHEMBL28637733 | 0.69 | MGLL (0.50) | NOTUMALDH1A1TSHRHSP90AA1TLR9 | |
| SCHEMBL3983615 | 0.69 | NOTUM (0.43) | NOTUMALDH1A1TSHRDAOCA12 | |
| SCHEMBL6417750 | 0.65 | HSP90AA1 (0.46) | NOTUMALDH1A1HSP90AA1DAOTLR9 | |
| SCHEMBL29851785 | 0.64 | HTR2A (0.40) | NOTUMALDH1A1TSHRDAOCA12 | |
| SCHEMBL1864062 | 0.64 | HTR2A (0.40) | NOTUMALDH1A1TSHRDAOCA12 | |
| SCHEMBL5917428 | 0.63 | NOTUM (0.41) | NOTUMALDH1A1TSHRDAOKDM4E | |
| SCHEMBL31717960 | 0.63 | RAB9A (0.47) | NOTUMALDH1A1TSHRDAOKDM4E | |
| SCHEMBL9259627 | 0.63 | NOTUM (1.00) | NOTUMALDH1A1TSHRDAOCA12 | |
| SCHEMBL30615209 | 0.63 | NOTUM (1.00) | NOTUMALDH1A1TSHRDAOCA12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0607864-B1 | Tricyclic condensed heterocyclic compounds for the treatment of senile dementic | TAKEDA CHEMICAL INDUSTRIES LTD (JP) | 2003-09-17 | — | — | EP | disclosed |
| EP-0655451-B1 | Tetracyclic condensed heterocyclic compounds for the treatment of senile dementia | TAKEDA CHEMICAL INDUSTRIES LTD (JP) | 2001-06-20 | — | — | EP | disclosed |
| US-5620973-A | CHOLINESTERASE INHIBITOR; ALZHEIMER*S DISEASE | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1997-04-15 | — | — | US | disclosed |
| US-5527800-A | A 4H-PYRROLO(3,2,1-IJ)QUINOLIN-8-YL DERIVATIVE ADMINISTERED FOR THERAPY OR PROPHYLAXIS OF SENILE DEMENTIA | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1996-06-18 | — | — | US | disclosed |
| EP-0655451-A1 | Tetracyclic condensed heterocyclic compounds for the treatment of senile dementia | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1995-05-31 | — | — | EP | disclosed |
| EP-0607864-A2 | Tricyclic condensed heterocyclic compounds for the treatment of senile dementic | Takeda Chemical Industries, Ltd. (JP) | 1994-07-27 | — | — | EP | disclosed |