Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Acetylcholine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM3 known ✓ | P20309 | 6/20 | 0.76 |
| ▸ | CHRM5 | P08912 | 6/20 | 0.76 |
| ▸ | CHRM1 | P11229 | 6/20 | 0.76 |
| ▸ | CHRM2 | P08172 | 5/20 | 0.76 |
| ▸ | CHRM4 | P08173 | 5/20 | 0.76 |
| ▸ | CHRNB2 | P17787 | 4/20 | 0.76 |
| ▸ | CHRNA4 | P43681 | 4/20 | 0.76 |
| ▸ | CHRNA7 | P36544 | 3/20 | 0.76 |
| ▸ | HTR1A | P08908 | 2/20 | 0.76 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.76 |
| ▸ | PGR | P06401 | 1/20 | 0.76 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.76 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.76 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.76 |
| ▸ | CHRNA10 | Q9GZZ6 | 1/20 | 0.76 |
| ▸ | CHRNA9 | Q9UGM1 | 1/20 | 0.76 |
| ▸ | GALR3 | O60755 | 2/20 | 0.73 |
| ▸ | GAA | P10253 | 1/20 | 0.73 |
| ▸ | RAB9A | P51151 | 1/20 | 0.73 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Acetylcholine SCHEMBL28054287 | 0.88 | CHRM1 (0.83) | CHRM5CHRM1CHRM3CHRM2CHRM4 | |
| Acetylcholine SCHEMBL2518957 | 0.87 | CHRM1 (1.00) | CHRM5CHRM1CHRM3CHRM2CHRM4 | |
| Acetylcholine SCHEMBL3216 | 0.87 | CHRM1 (1.00) | CHRM5CHRM1CHRM3CHRM2CHRM4 | |
| Acetylcholine SCHEMBL29441890 | 0.86 | CHRM1 (0.73) | CHRM5CHRM1CHRM3CHRM2CHRM4 | |
| Acetylcholine SCHEMBL28638398 | 0.86 | CHRM1 (0.79) | CHRM5CHRM1CHRM3CHRM2CHRM4 | |
| Acetylcholine SCHEMBL28047582 | 0.85 | CHRM5 (0.86) | CHRM5CHRM1CHRM3CHRM2CHRM4 | |
| Acetylcholine SCHEMBL3904052 | 0.85 | CHRM1 (0.95) | CHRM5CHRM1CHRM3CHRM2CHRM4 | |
| Acetylcholine SCHEMBL18227923 | 0.85 | CHRM1 (0.95) | CHRM5CHRM1CHRM3CHRM2CHRM4 | |
| Acetylcholine SCHEMBL8513991 | 0.85 | CHRM1 (0.95) | CHRM5CHRM1CHRM3CHRM2CHRM4 | |
| Acetylcholine SCHEMBL21925712 | 0.85 | CHRM1 (0.95) | CHRM5CHRM1CHRM3CHRM2CHRM4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-118382429-A | Ionic liquids for drug delivery | 哈佛大学校长及研究员协会 | 2024-07-23 | — | — | CN | disclosed |
| CN-113423800-A | Compositions comprising organic ammonium salts | 三吉油脂株式会社 | 2021-09-21 | — | — | CN | disclosed |