Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Acetylcholine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM3 known ✓ | P20309 | 8/20 | 0.95 |
| ▸ | CHRM1 | P11229 | 8/20 | 0.95 |
| ▸ | CHRM2 | P08172 | 7/20 | 0.95 |
| ▸ | CHRM4 | P08173 | 7/20 | 0.95 |
| ▸ | CHRM5 | P08912 | 6/20 | 0.95 |
| ▸ | CHRNB2 | P17787 | 4/20 | 0.95 |
| ▸ | CHRNA4 | P43681 | 4/20 | 0.95 |
| ▸ | CHRNA7 | P36544 | 3/20 | 0.95 |
| ▸ | HTR1A | P08908 | 2/20 | 0.95 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.95 |
| ▸ | PGR | P06401 | 1/20 | 0.95 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.95 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.95 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.95 |
| ▸ | CHRNA10 | Q9GZZ6 | 1/20 | 0.95 |
| ▸ | CHRNA9 | Q9UGM1 | 1/20 | 0.95 |
| ▸ | GALR3 | O60755 | 2/20 | 0.91 |
| ▸ | GAA | P10253 | 1/20 | 0.91 |
| ▸ | RAB9A | P51151 | 1/20 | 0.91 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.62 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Acetylcholine SCHEMBL3216 | 0.97 | CHRM1 (1.00) | CHRM1CHRM3CHRM2CHRM4CHRM5 | |
| Acetylcholine SCHEMBL2518957 | 0.97 | CHRM1 (1.00) | CHRM1CHRM3CHRM2CHRM4CHRM5 | |
| Acetylcholine SCHEMBL15687718 | 0.95 | CHRM1 (0.95) | CHRM1CHRM3CHRM2CHRM4CHRM5 | |
| Acetylcholine SCHEMBL21925712 | 0.95 | CHRM1 (0.95) | CHRM1CHRM3CHRM2CHRM4CHRM5 | |
| Acetylcholine SCHEMBL1157050 | 0.95 | CHRM1 (0.95) | CHRM1CHRM3CHRM2CHRM4CHRM5 | |
| Acetylcholine SCHEMBL1899186 | 0.95 | CHRM1 (0.95) | CHRM1CHRM3CHRM2CHRM4CHRM5 | |
| Acetylcholine SCHEMBL6023859 | 0.95 | CHRM1 (0.95) | CHRM1CHRM3CHRM2CHRM4CHRM5 | |
| Acetylcholine SCHEMBL8513991 | 0.95 | CHRM1 (0.95) | CHRM1CHRM3CHRM2CHRM4CHRM5 | |
| Acetylcholine SCHEMBL40885 | 0.95 | CHRM5 (1.00) | CHRM1CHRM3CHRM2CHRM4CHRM5 | |
| Acetylcholine SCHEMBL3904052 | 0.95 | CHRM1 (0.95) | CHRM1CHRM3CHRM2CHRM4CHRM5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-12622913-B2 | Folate salts for medical use | APROFOL AG (CH) | 2026-05-12 | — | — | US | disclosed |
| WO-2025262036-A1 | METHOD OF MANUFACTURING A PHARMACEUTICAL COMPOSITION | RNASSIST LTD (GB) | 2025-12-26 | — | — | WO | disclosed |
| EP-3827241-B1 | DISSOCIATION OF BIOLOGICAL SAMPLES | GOLDSBOROUGH ANDREW SIMON (FR) | 2024-03-13 | — | — | EP | disclosed |
| US-20240027309-A1 | SIMPLE FIXATION AND STABILISATION | RNASSIST LTD (GB) | 2024-01-25 | — | — | US | disclosed |
| US-20230277544-A1 | FOLATE SALTS FOR MEDICAL USE | APROFOL AG (CH) | 2023-09-07 | — | — | US | disclosed |
| US-20230220313-A1 | COMPOSITION AND METHOD FOR INACTIVATING A VIRUS | RNASSIST LTD. (GB) | 2023-07-13 | — | — | US | disclosed |
| US-11690846-B2 | Folate salts for medical use | APROFOL AG | 2023-07-04 | — | — | US | disclosed |
| EP-4133062-A1 | COMPOSITION AND METHOD FOR INACTIVATING A VIRUS | Rnassist Limited (GB) | 2023-02-15 | — | — | EP | disclosed |
| US-20200261460-A1 | FOLATE SALTS FOR MEDICAL USE | APROFOL AG (CH) | 2020-08-20 | — | — | US | disclosed |
| EP-3687995-A1 | FOLATE SALTS FOR MEDICAL USE | Aprofol AG (CH) | 2020-08-05 | — | — | EP | disclosed |
| CN-111448196-A | Folates for medical use | 阿普罗福尔公司 | 2020-07-24 | — | — | CN | disclosed |
| WO-2019063236-A1 | FOLATE SALTS FOR MEDICAL USE | APROFOL AG (CH) | 2019-04-04 | — | — | WO | disclosed |
| EP-3294452-A1 | PYROLYTIC METHOD FOR THE PRODUCTION OF PARTICLES CONTAINING AT LEAST ONE METAL SPECIES | Fraunhofer Gesellschaft zur Förderung der angewandten Forschung e.V. (DE) | 2018-03-21 | — | — | EP | disclosed |
| WO-2016180973-A1 | PYROLYTIC METHOD FOR THE PRODUCTION OF PARTICLES CONTAINING AT LEAST ONE METAL SPECIES | Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. (DE) | 2016-11-17 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20200261460-A1 | FOLATE SALTS FOR MEDICAL USE | FOLR2, FOLR1, MTHFD1 | CHRM3 176/4885CHRM1 102/4885CHRM2 61/4885 |
| US-11690846-B2 | Folate salts for medical use | FOLR2, FOLR1, MTHFD1 | CHRM3 176/4885CHRM1 102/4885CHRM2 61/4885 |
| US-20240027309-A1 | SIMPLE FIXATION AND STABILISATION | EWSR1, FOSB, PAXBP1 | CHRM3 4808/4885CHRM1 4831/4885CHRM2 4753/4885 |
| US-20230277544-A1 | FOLATE SALTS FOR MEDICAL USE | FOLR2, FOLR1, MTHFD1 | CHRM3 190/4885CHRM1 92/4885CHRM2 63/4885 |
| US-12622913-B2 | Folate salts for medical use | FOLR2, FOLR1, MTHFD1 | CHRM3 72/4885CHRM1 18/4885CHRM2 17/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.