Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNJ5 | P48544 | 3/20 | 0.47 |
| ▸ | KCNJ3 | P48549 | 3/20 | 0.47 |
| ▸ | TRPV1 | Q8NER1 | 3/20 | 0.41 |
| ▸ | NR2E1 | Q9Y466 | 2/20 | 0.40 |
| ▸ | RORA | P35398 | 1/20 | 0.40 |
| ▸ | RORC | P51449 | 2/20 | 0.39 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.38 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.38 |
| ▸ | RET | P07949 | 2/20 | 0.38 |
| ▸ | WNT3A | P56704 | 1/20 | 0.38 |
| ▸ | P2RX4 | Q99571 | 1/20 | 0.38 |
| ▸ | KCNJ6 | P48051 | 1/20 | 0.37 |
| ▸ | ANO1 | Q5XXA6 | 1/20 | 0.37 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28645373 | 1.00 | KCNJ5 (0.47) | KCNJ5KCNJ3TRPV1NR2E1RORA | |
| SCHEMBL19205697 | 0.93 | KCNJ5 (0.48) | KCNJ5KCNJ3TRPV1NR2E1RORA | |
| SCHEMBL28641213 | 0.90 | RORC (0.40) | KCNJ5KCNJ3TRPV1RORCRET | |
| SCHEMBL28638482 | 0.89 | KCNJ5 (0.49) | KCNJ5KCNJ3TRPV1NR2E1RORA | |
| SCHEMBL28638488 | 0.86 | PSMB5 (0.41) | TRPV1RORCRETWNT3A | |
| SCHEMBL19205696 | 0.85 | RORC (0.44) | KCNJ5KCNJ3TRPV1RORCRET | |
| SCHEMBL21796352 | 0.85 | RORC (0.44) | KCNJ5KCNJ3TRPV1RORCRET | |
| SCHEMBL18447911 | 0.85 | RORC (0.44) | KCNJ5KCNJ3TRPV1RORCRET | |
| SCHEMBL19205666 | 0.85 | WNT3A (0.43) | RORCRETWNT3A | |
| SCHEMBL18449666 | 0.84 | RORC (0.44) | KCNJ5KCNJ3TRPV1RORCRET |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-108026050-B | Novel compounds as ROR gamma modulators | 格兰马克药品股份有限公司 | 2021-04-30 | — | — | CN | claimed |