Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.42 |
| ▸ | TSHR | P16473 | 3/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.39 |
| ▸ | EGFR | P00533 | 2/20 | 0.37 |
| ▸ | MAPT | P10636 | 3/20 | 0.37 |
| ▸ | CTSB | P07858 | 2/20 | 0.37 |
| ▸ | CTSH | P09668 | 1/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | GPR35 | Q9HC97 | 1/20 | 0.36 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.35 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.35 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 3/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.35 |
| ▸ | NPC1 | O15118 | 2/20 | 0.35 |
| ▸ | RAB9A | P51151 | 2/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | NCOA1 | Q15788 | 1/20 | 0.35 |
| ▸ | NCOA3 | Q9Y6Q9 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28656976 | 0.81 | TDP1 (0.43) | TDP1TSHRSMN1; SMN2EGFRMAPT | |
| SCHEMBL28461861 | 0.81 | EGFR (0.37) | TDP1TSHRSMN1; SMN2EGFRMAPT | |
| SCHEMBL17827803 | 0.74 | MAPT (0.39) | SMN1; SMN2MAPTLMNAKDM4EHTT | |
| SCHEMBL17827758 | 0.71 | — | — | |
| SCHEMBL2621725 | 0.71 | LMNA (0.33) | SMN1; SMN2LMNAHTT | |
| SCHEMBL13866495 | 0.71 | PARP1 (0.50) | TDP1TSHRSMN1; SMN2CYP3A4KDM4E | |
| SCHEMBL17827763 | 0.70 | METAP2 (0.30) | METAP2 | |
| SCHEMBL22831863 | 0.70 | L3MBTL1 (0.52) | TDP1SMN1; SMN2MAPTRAB9AKDM4E | |
| SCHEMBL29562103 | 0.70 | L3MBTL1 (0.52) | TDP1SMN1; SMN2MAPTRAB9AKDM4E | |
| SCHEMBL31481283 | 0.69 | TDP1 (0.50) | TDP1TSHRSMN1; SMN2MAPTCTSB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-113527215-B | Quinazoline compound, preparation method and application thereof | 北京赛特明强医药科技有限公司 | 2023-12-05 | — | — | CN | disclosed |
| CN-113527215-A | Quinazoline compound, preparation method and application thereof | 北京赛特明强医药科技有限公司 | 2021-10-22 | — | — | CN | disclosed |