Known targets — ChEMBL curated mechanism
ABL1BMXBRAFBTKCHRNA4CHRNB2CSNK1EEGFRERBB2F10FLT1FLT3FLT4IGF1RINSRITKJAK3KDRKITOPRM1PARP1PARP2PDGFRBPIK3CDRAF1RETSLC18A2TECTXKdacAdacBdacCftsImrcAmrcBmrdArplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of None. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | LTA4H | P09960 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | CA1 | P00915 | 3/20 | 0.43 |
| ▸ | CA2 | P00918 | 3/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.42 |
| ▸ | MMP2 | P08253 | 3/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.40 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.40 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.40 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.40 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.40 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.40 |
| ▸ | DPP8 | Q6V1X1 | 2/20 | 0.40 |
| ▸ | DPP7 | Q9UHL4 | 2/20 | 0.40 |
| ▸ | EPOR | P19235 | 1/20 | 0.40 |
| ▸ | DPP4 | P27487 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20572531 | 1.00 | LMNA (0.47) | LMNALTA4HMAPTCA1CA2 | |
| SCHEMBL7803936 | 1.00 | LMNA (0.47) | LMNALTA4HMAPTCA1CA2 | |
| SCHEMBL29104388 | 0.99 | LMNA (0.46) | LMNALTA4HMAPTCA1CA2 | |
| SCHEMBL30544855 | 0.92 | LTA4H (0.49) | LTA4HCA1CA2MMP2DPP8 | |
| SCHEMBL11688967 | 0.90 | LMNA (0.46) | LMNAMAPTCA1CA2 | |
| SCHEMBL28847759 | 0.90 | LMNA (0.48) | LMNAMAPTCA1CA2CYP1A2 | |
| SCHEMBL7274648 | 0.90 | LMNA (0.48) | LMNAMAPTCA1CA2CYP1A2 | |
| SCHEMBL28847755 | 0.89 | LMNA (0.47) | LMNAMAPTCA1CA2CYP1A2 | |
| SCHEMBL11203979 | 0.89 | LMNA (0.47) | LMNALTA4HMAPTCA1CA2 | |
| SCHEMBL8090627 | 0.88 | LTA4H (0.46) | LMNALTA4HCA1CA2MMP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-113621129-A | Bio-based waterborne polyurethane resin and preparation method and application thereof | 广安摩珈生物科技有限公司 | 2021-11-09 | — | — | CN | disclosed |
| CN-113336664-A | Bio-based waterborne polyurethane resin and preparation method and application thereof | 广安摩珈生物科技有限公司 | 2021-09-03 | — | — | CN | disclosed |