Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TAAR1 | Q96RJ0 | 6/20 | 0.47 |
| ▸ | HTR2A | P28223 | 2/20 | 0.44 |
| ▸ | HTR2C | P28335 | 2/20 | 0.44 |
| ▸ | HTR2B | P41595 | 2/20 | 0.44 |
| ▸ | MAOB | P27338 | 2/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | ATM | Q13315 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 2/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.39 |
| ▸ | GLA | P06280 | 1/20 | 0.39 |
| ▸ | TUBB4A | P04350 | 1/20 | 0.38 |
| ▸ | TUBB | P07437 | 1/20 | 0.38 |
| ▸ | TUBA3C | P0DPH7 | 1/20 | 0.38 |
| ▸ | TUBA1B | P68363 | 1/20 | 0.38 |
| ▸ | TUBA4A | P68366 | 1/20 | 0.38 |
| ▸ | TUBB4B | P68371 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2760680 | 0.82 | LOXL2 (0.44) | TAAR1MAOBTUBB4ATUBBTUBA3C | |
| Hydrochloric Acid SCHEMBL18130127 | 0.80 | LOXL2 (0.42) | MAOBTUBB4ATUBBTUBA3CTUBA1B | |
| SCHEMBL19219145 | 0.79 | TUBB4A (0.36) | HTR2ATUBB4ATUBBTUBA3CTUBA1B | |
| SCHEMBL26393934 | 0.75 | CASP3 (0.51) | HTR2AHTR2CKDM4EATMTSHR | |
| SCHEMBL19219147 | 0.75 | TLR7 (0.36) | TSHRCYP1A2CYP3A4TUBB4ATUBB | |
| SCHEMBL7980765 | 0.75 | CHRM2 (0.39) | KDM4EGLATUBB4ATUBBTUBA3C | |
| SCHEMBL20520312 | 0.75 | GRM2 (0.41) | LMNA | |
| SCHEMBL8008816 | 0.75 | TUBB4A (0.41) | KDM4ETUBB4ATUBBTUBA3CTUBA1B | |
| SCHEMBL2172820 | 0.75 | TAAR1 (0.46) | TAAR1HTR2AKDM4ECYP1A2CYP2A6 | |
| SCHEMBL23816857 | 0.74 | CASP3 (0.50) | HTR2AHTR2CKDM4EATMLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2139334-A1 | 2-CYANOPHENYL FUSED HETEROCYCLIC COMPOUNDS, AND COMPOSITIONS AND USES THEREOF | Renovis, Inc. (US) | 2010-01-06 | — | — | EP | disclosed |
| WO-2008130481-A1 | 2-CYANOPHENYL FUSED HETEROCYCLIC COMPOUNDS, AND COMPOSITIONS AND USES THEREOF | RENOVIS, INC. (US) | 2008-10-30 | — | — | WO | disclosed |