Known targets — ChEMBL curated mechanism
BTKCACNA1CCACNA1DCACNA1FCACNA1SCACNA2D1CACNA2D2DRD2GABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQHRH1HTR2AP2RY12
The experimentally established mechanism targets of None. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRAF | P15056 | 13/20 | 0.89 |
| ▸ | KDR | P35968 | 12/20 | 0.89 |
| ▸ | IKBKB | O14920 | 2/20 | 0.89 |
| ▸ | RAF1 | P04049 | 2/20 | 0.89 |
| ▸ | CDK1 | P06493 | 2/20 | 0.89 |
| ▸ | PDGFRB | P09619 | 2/20 | 0.89 |
| ▸ | FGFR3 | P22607 | 2/20 | 0.89 |
| ▸ | MAP2K1 | Q02750 | 2/20 | 0.89 |
| ▸ | TEK | Q02763 | 2/20 | 0.89 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.89 |
| ▸ | AURKB | Q96GD4 | 2/20 | 0.89 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.89 |
| ▸ | KIT | P10721 | 1/20 | 0.89 |
| ▸ | SRC | P12931 | 1/20 | 0.89 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.89 |
| ▸ | RIPK3 | Q9Y572 | 8/20 | 0.36 |
| ▸ | RIPK1 | Q13546 | 7/20 | 0.36 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.36 |
| ▸ | PDGFA | P04085 | 1/20 | 0.36 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Sulfuric Acid SCHEMBL2857480 | 0.95 | BRAF (0.95) | BRAFKDRIKBKBRAF1CDK1 | |
| SCHEMBL2851317 | 0.94 | BRAF (1.00) | BRAFKDRIKBKBRAF1CDK1 | |
| SCHEMBL2864264 | 0.84 | BRAF (0.69) | BRAFKDRIKBKBRAF1CDK1 | |
| SCHEMBL2857485 | 0.83 | BRAF (0.72) | BRAFKDRIKBKBRAF1CDK1 | |
| SCHEMBL2851221 | 0.81 | BRAF (1.00) | BRAFKDRIKBKBRAF1CDK1 | |
| SCHEMBL2864298 | 0.74 | KDR (0.69) | BRAFKDRIKBKBRAF1CDK1 | |
| SCHEMBL2858950 | 0.73 | BRAF (0.74) | BRAFKDRIKBKBRAF1CDK1 | |
| SCHEMBL2454836 | 0.72 | BRAF (0.61) | BRAFKDRIKBKBRAF1CDK1 | |
| SCHEMBL13354087 | 0.71 | BRAF (0.63) | BRAFKDRIKBKBRAF1CDK1 | |
| SCHEMBL2856506 | 0.71 | KDR (0.74) | BRAFKDRIKBKBRAF1CDK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8344135-B2 | Heterocyclic compound and use thereof | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2013-01-01 | — | — | US | claimed |
| US-20100249119-A1 | HETEROCYCLIC COMPOUND AND USE THEREOF | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2010-09-30 | — | — | US | claimed |
| EP-2184285-A1 | HETEROCYCLIC COMPOUND AND USE THEREOF | Takeda Pharmaceutical Company Limited (JP) | 2010-05-12 | — | — | EP | claimed |
| US-8344135-B2 | Heterocyclic compound and use thereof | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2013-01-01 | — | — | US | disclosed |
| US-20100249119-A1 | HETEROCYCLIC COMPOUND AND USE THEREOF | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2010-09-30 | — | — | US | disclosed |
| EP-2184285-A1 | HETEROCYCLIC COMPOUND AND USE THEREOF | Takeda Pharmaceutical Company Limited (JP) | 2010-05-12 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100249119-A1 | HETEROCYCLIC COMPOUND AND USE THEREOF | BRAF, NRAS, RAF1 | BRAF 1/4885KDR 983/4885IKBKB 212/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.