Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 2/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | LRRK2 | Q5S007 | 2/20 | 0.37 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | ACHE | P22303 | 1/20 | 0.33 |
| ▸ | RXRA | P19793 | 1/20 | 0.33 |
| ▸ | HNF4A | P41235 | 1/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28926168 | 0.88 | MEN1 (0.39) | KMT2ATSHRHSD17B10LRRK2KDM4E | |
| SCHEMBL28643695 | 0.85 | LRRK2 (0.37) | TSHRHSD17B10LRRK2ALOX15KDM4E | |
| SCHEMBL28645763 | 0.83 | KMT2A (0.41) | KMT2ATSHRHSD17B10ALOX15 | |
| SCHEMBL28633462 | 0.81 | KMT2A (0.53) | KMT2AALOX15TP53 | |
| SCHEMBL28652352 | 0.80 | KMT2A (0.48) | KMT2ATSHRALOX15KDM4ETP53 | |
| SCHEMBL30604612 | 0.79 | KMT2A (0.47) | KMT2ATSHRCYP3A4LMNA | |
| SCHEMBL28656930 | 0.79 | KMT2A (0.45) | KMT2ATSHRHSD17B10ALOX15TP53 | |
| SCHEMBL30604606 | 0.79 | KMT2A (0.45) | KMT2ATSHRHSD17B10ALOX15TP53 | |
| SCHEMBL28638917 | 0.79 | KMT2A (0.47) | KMT2ATSHRCYP3A4LMNA | |
| SCHEMBL28644853 | 0.76 | LRRK2 (0.42) | KMT2ATSHRLRRK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-113493438-B | Tetrahydroisoquinoline compounds | 南京再明医药有限公司 | 2023-10-20 | — | — | CN | disclosed |
| CN-113493438-A | Tetrahydroisoquinoline compounds | 江苏先声药业有限公司 | 2021-10-12 | — | — | CN | disclosed |