Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PKM | P14618 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.36 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.36 |
| ▸ | GSK3A | P49840 | 1/20 | 0.35 |
| ▸ | GSK3B | P49841 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | DRD2 | P14416 | 1/20 | 0.34 |
| ▸ | DRD3 | P35462 | 1/20 | 0.34 |
| ▸ | NPY1R | P25929 | 3/20 | 0.34 |
| ▸ | NPY4R | P50391 | 1/20 | 0.34 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | MGLL | Q99685 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | CA2 | P00918 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | AKT1 | P31749 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Trifluoroacetic Acid SCHEMBL20263649 | 0.99 | PKM (0.41) | PKMLMNAADORA2AADORA1GSK3A | |
| SCHEMBL29398497 | 0.91 | LMNA (0.42) | PKMLMNAGSK3AGSK3BNPC1 | |
| SCHEMBL17841923 | 0.90 | MGLL (0.42) | PKMLMNAGSK3AGSK3BNPC1 | |
| SCHEMBL17841834 | 0.90 | MGLL (0.42) | PKMLMNAGSK3AGSK3BNPC1 | |
| SCHEMBL24797605 | 0.90 | MGLL (0.42) | PKMLMNAGSK3AGSK3BNPC1 | |
| SCHEMBL24798072 | 0.90 | MGLL (0.42) | PKMLMNAGSK3AGSK3BNPC1 | |
| Trifluoroacetic Acid SCHEMBL29467754 | 0.87 | MGLL (0.40) | ADORA2AADORA1DRD2DRD3NPY1R | |
| Trifluoroacetic Acid SCHEMBL18261651 | 0.87 | PKM (0.38) | PKMLMNAGSK3AGSK3BDRD2 | |
| SCHEMBL13541914 | 0.84 | LMNA (0.47) | PKMLMNAGSK3AGSK3BNPC1 | |
| Trifluoroacetic Acid SCHEMBL20677193 | 0.83 | PTGS1 (0.44) | PKMLMNAADORA2AADORA1DRD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-116059390-A | Prodrugs of cytotoxic actives with enzymatically cleavable groups | 拜耳制药股份公司 | 2023-05-05 | — | — | CN | disclosed |
| CN-114917361-A | Antibody Drug Conjugates (ADC) and antibody prodrug conjugates (APDC) with enzyme cleavable groups | 拜耳医药股份有限公司 | 2022-08-19 | — | — | CN | disclosed |
| CN-107635586-B | Antibody-drug conjugates (ADC) of KSP inhibitors with aglycosylated anti-TWEAKR antibodies | 拜耳医药股份有限公司 | 2021-09-24 | — | — | CN | disclosed |