Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TNKS | O95271 | 3/20 | 0.41 |
| ▸ | ATR | Q13535 | 2/20 | 0.39 |
| ▸ | BRD4 | O60885 | 1/20 | 0.39 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.39 |
| ▸ | MET | P08581 | 1/20 | 0.39 |
| ▸ | TDO2 | P48775 | 1/20 | 0.37 |
| ▸ | BACE1 | P56817 | 1/20 | 0.37 |
| ▸ | BACE2 | Q9Y5Z0 | 1/20 | 0.37 |
| ▸ | CNR2 | P34972 | 1/20 | 0.37 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.36 |
| ▸ | ATM | Q13315 | 1/20 | 0.36 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.36 |
| ▸ | FYN | P06241 | 3/20 | 0.35 |
| ▸ | RPS6KA3 | P51812 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28645594 | 0.75 | TNKS (0.42) | TNKSATRBRD4CREBBPMET | |
| SCHEMBL29929921 | 0.71 | TDO2 (0.44) | TNKSATRMETTDO2BACE1 | |
| SCHEMBL28642686 | 0.71 | TDO2 (0.44) | TNKSATRMETTDO2BACE1 | |
| SCHEMBL29929741 | 0.69 | MAP4K1 (0.51) | TNKSATRTDO2 | |
| SCHEMBL28631971 | 0.69 | MAP4K1 (0.51) | TNKSATRTDO2 | |
| SCHEMBL3241755 | 0.68 | CNR2 (0.56) | TNKSATRBRD4CREBBPMET | |
| SCHEMBL10094621 | 0.66 | CYP1A2 (0.57) | TNKSBRD4CREBBPMETTDO2 | |
| SCHEMBL19951649 | 0.66 | TNKS (0.53) | TNKSATRBRD4CREBBPTDO2 | |
| SCHEMBL28642628 | 0.66 | MAP4K1 (0.44) | TNKSATRMETTDO2BACE1 | |
| SCHEMBL31514576 | 0.64 | HRH4 (0.48) | TNKSATRMETTDO2HDAC2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-113336747-A | Novel HPK1 inhibitor and preparation method and application thereof | 轶诺(浙江)药业有限公司 | 2021-09-03 | — | — | CN | disclosed |