Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR119 | Q8TDV5 | 9/20 | 0.43 |
| ▸ | ALOX5AP | P20292 | 5/20 | 0.40 |
| ▸ | FEN1 | P39748 | 5/20 | 0.40 |
| ▸ | NSD2 | O96028 | 1/20 | 0.39 |
| ▸ | RET | P07949 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | EGFR | P00533 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28927877 | 0.90 | MAP4K1 (0.36) | — | |
| SCHEMBL28927875 | 0.83 | GPR119 (0.39) | GPR119ALOX5APFEN1NSD2RET | |
| SCHEMBL28636439 | 0.83 | MAP3K7 (0.51) | RET | |
| SCHEMBL28638645 | 0.82 | MAP4K3 (0.39) | — | |
| SCHEMBL28927868 | 0.81 | GPR119 (0.38) | GPR119ALOX5APFEN1NSD2RET | |
| SCHEMBL28927858 | 0.80 | RET (0.43) | GPR119NSD2RET | |
| SCHEMBL28927854 | 0.80 | MAP4K1 (0.42) | GPR119ALOX5APFEN1NSD2RET | |
| SCHEMBL163981 | 0.70 | GPR119 (0.47) | GPR119ALOX5APFEN1 | |
| SCHEMBL17151815 | 0.70 | POLB (0.49) | GPR119ALOX5APFEN1TP53 | |
| SCHEMBL11946811 | 0.70 | TP53 (0.40) | ALOX5APFEN1TP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115244050-B | Novel HPK1 inhibitor and preparation method and application thereof | 轶诺(浙江)药业有限公司 | 2024-06-21 | — | — | CN | disclosed |
| CN-115244050-A | Novel HPK1 inhibitor and preparation method and application thereof | 轶诺(浙江)药业有限公司 | 2022-10-25 | — | — | CN | disclosed |
| CN-113336747-A | Novel HPK1 inhibitor and preparation method and application thereof | 轶诺(浙江)药业有限公司 | 2021-09-03 | — | — | CN | disclosed |