Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR119 | Q8TDV5 | 6/20 | 0.39 |
| ▸ | MAP3K7 | O43318 | 2/20 | 0.38 |
| ▸ | TAB1 | Q15750 | 2/20 | 0.38 |
| ▸ | NSD2 | O96028 | 1/20 | 0.37 |
| ▸ | BTK | Q06187 | 1/20 | 0.36 |
| ▸ | RET | P07949 | 3/20 | 0.36 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.36 |
| ▸ | ABL1 | P00519 | 2/20 | 0.36 |
| ▸ | EGFR | P00533 | 2/20 | 0.36 |
| ▸ | SRC | P12931 | 2/20 | 0.36 |
| ▸ | ABL2 | P42684 | 2/20 | 0.36 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.36 |
| ▸ | FEN1 | P39748 | 1/20 | 0.36 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.36 |
| ▸ | TNK2 | Q07912 | 1/20 | 0.36 |
| ▸ | KDM1A | O60341 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28927868 | 0.93 | GPR119 (0.38) | GPR119MAP3K7TAB1NSD2BTK | |
| SCHEMBL28636439 | 0.89 | MAP3K7 (0.51) | MAP3K7TAB1RETTNK2 | |
| SCHEMBL28927885 | 0.85 | MAP4K3 (0.43) | MAP3K7TAB1KDM1A | |
| SCHEMBL28645666 | 0.83 | GPR119 (0.43) | GPR119NSD2RETEGFRALOX5AP | |
| SCHEMBL28927858 | 0.80 | RET (0.43) | GPR119NSD2RET | |
| SCHEMBL28927854 | 0.80 | MAP4K1 (0.42) | GPR119NSD2RETALOX5APFEN1 | |
| SCHEMBL28962175 | 0.78 | KDM1A (0.45) | KDM1A | |
| SCHEMBL29929924 | 0.76 | MAP3K7 (0.47) | MAP3K7TAB1 | |
| SCHEMBL28962176 | 0.75 | MAP4K1 (0.38) | KDM1A | |
| SCHEMBL28634046 | 0.73 | MAP4K3 (0.59) | MAP3K7TAB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115244050-B | Novel HPK1 inhibitor and preparation method and application thereof | 轶诺(浙江)药业有限公司 | 2024-06-21 | — | — | CN | disclosed |
| CN-115244050-A | Novel HPK1 inhibitor and preparation method and application thereof | 轶诺(浙江)药业有限公司 | 2022-10-25 | — | — | CN | disclosed |