Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP4K3 | Q8IVH8 | 4/20 | 0.39 |
| ▸ | CHRNB2 | P17787 | 2/20 | 0.36 |
| ▸ | CHRNA4 | P43681 | 2/20 | 0.36 |
| ▸ | MAP4K1 | Q92918 | 1/20 | 0.36 |
| ▸ | KDM1A | O60341 | 3/20 | 0.35 |
| ▸ | TLR9 | Q9NR96 | 3/20 | 0.34 |
| ▸ | TLR8 | Q9NR97 | 3/20 | 0.34 |
| ▸ | TLR7 | Q9NYK1 | 3/20 | 0.34 |
| ▸ | HTR1A | P08908 | 1/20 | 0.33 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.33 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.33 |
| ▸ | RORC | P51449 | 1/20 | 0.32 |
| ▸ | JAK2 | O60674 | 1/20 | 0.32 |
| ▸ | IKBKB | O14920 | 2/20 | 0.32 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.31 |
| ▸ | PIM1 | P11309 | 1/20 | 0.31 |
| ▸ | PIM3 | Q86V86 | 1/20 | 0.31 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28927877 | 0.86 | MAP4K1 (0.36) | MAP4K1KDM1ARORC | |
| SCHEMBL28645666 | 0.82 | GPR119 (0.43) | — | |
| SCHEMBL28927885 | 0.79 | MAP4K3 (0.43) | MAP4K3CHRNB2CHRNA4MAP4K1KDM1A | |
| SCHEMBL28634046 | 0.79 | MAP4K3 (0.59) | MAP4K3CHRNB2CHRNA4 | |
| SCHEMBL28962175 | 0.76 | KDM1A (0.45) | MAP4K3MAP4K1KDM1AJAK2 | |
| SCHEMBL28927866 | 0.75 | MAP4K1 (0.46) | MAP4K1PIM1 | |
| SCHEMBL28927864 | 0.75 | PIM1 (0.43) | MAP4K1PIM1PIM3PIM2 | |
| SCHEMBL28633555 | 0.74 | MAP4K1 (0.42) | MAP4K1KDM1ARORC | |
| SCHEMBL28927863 | 0.74 | MAP4K1 (0.34) | MAP4K1KDM1AHTR1ASLC6A2SLC6A4 | |
| SCHEMBL28925081 | 0.68 | MAP4K1 (0.43) | MAP4K1KDM1ARORC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115244050-B | Novel HPK1 inhibitor and preparation method and application thereof | 轶诺(浙江)药业有限公司 | 2024-06-21 | — | — | CN | disclosed |
| CN-115244050-A | Novel HPK1 inhibitor and preparation method and application thereof | 轶诺(浙江)药业有限公司 | 2022-10-25 | — | — | CN | disclosed |
| CN-113336747-A | Novel HPK1 inhibitor and preparation method and application thereof | 轶诺(浙江)药业有限公司 | 2021-09-03 | — | — | CN | disclosed |