Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RPS6KA5 | O75582 | 8/20 | 0.49 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.47 |
| ▸ | CDK2 | P24941 | 1/20 | 0.47 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.47 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.47 |
| ▸ | RPS6KA1 | Q15418 | 1/20 | 0.47 |
| ▸ | S1PR1 | P21453 | 2/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
| ▸ | KDM5A | P29375 | 1/20 | 0.42 |
| ▸ | PTGER4 | P35408 | 2/20 | 0.41 |
| ▸ | SLC22A12 | Q96S37 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | CASP1 | P29466 | 1/20 | 0.40 |
| ▸ | CASP7 | P55210 | 1/20 | 0.40 |
| ▸ | ATM | Q13315 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | RECQL | P46063 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23624032 | 0.84 | RPS6KA5 (0.49) | RPS6KA5RPS6KB1CDK2ROCK1DYRK1A | |
| SCHEMBL3619365 | 0.80 | MAPK1 (0.61) | CYP2D6MAPK1CASP1CASP7ALDH1A1 | |
| SCHEMBL13071643 | 0.78 | RPS6KA5 (0.54) | RPS6KA5RPS6KB1CDK2ROCK1DYRK1A | |
| SCHEMBL4717496 | 0.72 | TP53 (0.47) | RPS6KA5RPS6KB1CDK2ROCK1DYRK1A | |
| SCHEMBL28635648 | 0.72 | RPS6KA5 (0.48) | RPS6KA5CYP2D6CYP2C19SLC22A12ATM | |
| SCHEMBL8322125 | 0.71 | L3MBTL1 (0.46) | RPS6KA5ATM | |
| SCHEMBL12085751 | 0.70 | GPR35 (0.55) | KDM5APTGER4ALDH1A1 | |
| SCHEMBL13497676 | 0.70 | S1PR1 (0.54) | RPS6KA5RPS6KB1CDK2ROCK1DYRK1A | |
| SCHEMBL7496365 | 0.70 | — | — | |
| SCHEMBL7501624 | 0.69 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-113348170-B | Biphenyl derivative inhibitor, preparation method and application thereof | 上海翰森生物医药科技有限公司 | 2023-12-22 | — | — | CN | disclosed |
| CN-113348170-A | Biphenyl derivative inhibitor, preparation method and application thereof | 上海翰森生物医药科技有限公司 | 2021-09-03 | — | — | CN | disclosed |