SCHEMBL28645951

SCHEMBL28645951

O=Cc1cc2c(c(OCc3ccccc3)c1)OCCC2

nearest known ligand 0.43

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAOB P27338 7/20 0.43
MAOA P21397 6/20 0.43
CCNB2 O95067 1/20 0.40
CDK1 P06493 1/20 0.40
CDK4 P11802 1/20 0.40
CCNB1 P14635 1/20 0.40
CCND1 P24385 1/20 0.40
CCNB3 Q8WWL7 1/20 0.40
SMN1; SMN2 Q16637 4/20 0.38
L3MBTL1 Q9Y468 2/20 0.38
NPC1 O15118 2/20 0.38
RAB9A P51151 2/20 0.38
MAPT P10636 2/20 0.38
KMT2A Q03164 2/20 0.38
TDP1 Q9NUW8 1/20 0.38
HTR1A P08908 1/20 0.37
SLC6A4 P31645 1/20 0.37
ALDH1A1 P00352 3/20 0.37
HPGD P15428 3/20 0.37
NFKB1 P19838 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL31405801 1.00 MAOB (0.43) MAOBMAOACCNB2CDK1CDK4
SCHEMBL30079624 0.93 MAOB (0.45) MAOBMAOACCNB2CDK1CDK4
SCHEMBL21893388 0.93 MAOB (0.45) MAOBMAOACCNB2CDK1CDK4
SCHEMBL11128563 0.82 BCHE (0.41) MAOBMAOANPC1RAB9AHTR1A
SCHEMBL31405805 0.81 KDM1A (0.43) MAOBMAOANPC1RAB9AHTR1A
SCHEMBL28634229 0.81 KDM1A (0.43) MAOBMAOANPC1RAB9AHTR1A
SCHEMBL23698998 0.80 RXRB (0.48) MAOBMAOACCNB2CDK1CDK4
SCHEMBL11124024 0.76 PIN1 (0.40) MAOBMAOANPC1RAB9AHTR1A
SCHEMBL1620222 0.76 ALDH1A1 (0.41) MAOBL3MBTL1KMT2ATDP1ALDH1A1
SCHEMBL11123825 0.76 KDM4E (0.44) SMN1; SMN2NPC1RAB9AMAPTKMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-113444102-A Fused tetracyclic compounds and application thereof in medicines 广东东阳光药业有限公司 2021-09-28 CN disclosed