Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TOP1 | P11387 | 18/20 | 0.93 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.93 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.93 |
| ▸ | MEN1 | O00255 | 4/20 | 0.93 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.93 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.93 |
| ▸ | GLA | P06280 | 3/20 | 0.93 |
| ▸ | TP53 | P04637 | 2/20 | 0.93 |
| ▸ | HPGD | P15428 | 2/20 | 0.93 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.93 |
| ▸ | HBB | P68871 | 2/20 | 0.93 |
| ▸ | RAB9A | P51151 | 2/20 | 0.93 |
| ▸ | BLM | P54132 | 2/20 | 0.93 |
| ▸ | STAT6 | P42226 | 1/20 | 0.93 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.93 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.93 |
| ▸ | ABCC4 | O15439 | 1/20 | 0.93 |
| ▸ | GMNN | O75496 | 1/20 | 0.93 |
| ▸ | LMNA | P02545 | 1/20 | 0.93 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.93 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Camptothecin SCHEMBL5967412 | 0.97 | TOP1 (0.95) | TOP1ALDH1A1KDM4EMEN1KMT2A | |
| Camptothecin SCHEMBL29360250 | 0.96 | TOP1 (1.00) | TOP1ALDH1A1KDM4EMEN1KMT2A | |
| Camptothecin SCHEMBL29351099 | 0.96 | TOP1 (1.00) | TOP1ALDH1A1KDM4EMEN1KMT2A | |
| Camptothecin SCHEMBL28057307 | 0.96 | TOP1 (1.00) | TOP1ALDH1A1KDM4EMEN1KMT2A | |
| Camptothecin SCHEMBL6038 | 0.96 | TOP1 (1.00) | TOP1ALDH1A1KDM4EMEN1KMT2A | |
| Camptothecin SCHEMBL4304557 | 0.96 | TOP1 (1.00) | TOP1ALDH1A1KDM4EMEN1KMT2A | |
| Camptothecin SCHEMBL788063 | 0.96 | TOP1 (1.00) | TOP1ALDH1A1KDM4EMEN1KMT2A | |
| Camptothecin SCHEMBL29369924 | 0.96 | TOP1 (1.00) | TOP1ALDH1A1KDM4EMEN1KMT2A | |
| Camptothecin SCHEMBL2298909 | 0.96 | TOP1 (1.00) | TOP1ALDH1A1KDM4EMEN1KMT2A | |
| Camptothecin SCHEMBL23929267 | 0.96 | TOP1 (0.88) | TOP1ALDH1A1KDM4EMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7771727-B2 | Conjugates of therapeutic or cytotoxic agents and biologically active peptides | THE ADMINISTRATORS OF THE TULANE EDUCATIONAL FUND (US) | 2010-08-10 | — | — | US | disclosed |
| EP-1487493-B1 | CONJUGATES OF CYTOTOXIC AGENTS AND BIOLOGICALLY ACTIVE PEPTIDES | UNIV TULANE (US) | 2010-01-20 | — | — | EP | disclosed |
| US-20090324620-A1 | CONJUGATES OF THERAPEUTIC OR CYTOTOXIC AGENTS AND BIOLOGICALLY ACTIVE PEPTIDES | THE ADMINISTRATORS OF THE TULANE EDUCATIONAL FUND (US) | 2009-12-31 | — | — | US | disclosed |
| EP-1487493-A4 | CONJUGATES OF THERAPEUTIC OR CYTOTOXIC AGENTS AND BIOLOGICALLY ACTIVE PEPTIDES | UNIV TULANE (US) | 2006-08-30 | — | — | EP | disclosed |
| US-20060009622-A1 | Conjugates of therapeutic or cytotoxic agents and biologically active peptides | ADMINISTRATORS OF THE TULANE EDUCATIONAL FUND, THE | 2006-01-12 | — | — | US | disclosed |
| EP-1487493-A2 | CONJUGATES OF THERAPEUTIC OR CYTOTOXIC AGENTS AND BIOLOGICALLY ACTIVE PEPTIDES | The Administrators of The Tulane Educational Fund (US) | 2004-12-22 | — | — | EP | disclosed |
| WO-2003074551-A2 | CONJUGATES OF THERAPEUTIC OR CYTOTOXIC AGENTS AND BIOLOGICALLY ACTIVE PEPTIDES | THE ADMINISTRATORS OF THE TULANE EDUCATIONAL FUND (US) | 2003-09-12 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090324620-A1 | CONJUGATES OF THERAPEUTIC OR CYTOTOXIC AGENTS AND BIOLOGICALLY ACTIVE PEPTIDES | MCL1, DNPEP, TP53 | TOP1 432/4885ALDH1A1 3043/4885KDM4E 4705/4885 |
| US-20060009622-A1 | Conjugates of therapeutic or cytotoxic agents and biologically active peptides | MCL1, DNPEP, TP53 | TOP1 432/4885ALDH1A1 3043/4885KDM4E 4705/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.