Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Bicarbonate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTH | P32929 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 3/20 | 0.39 |
| ▸ | IDO1 | P14902 | 1/20 | 0.38 |
| ▸ | GLRA1 | P23415 | 1/20 | 0.35 |
| ▸ | SLC6A9 | P48067 | 1/20 | 0.35 |
| ▸ | OR51E2 | Q9H255 | 1/20 | 0.35 |
| ▸ | THRB | P10828 | 3/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.33 |
| ▸ | BLM | P54132 | 2/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.33 |
| ▸ | GABRR3 | A8MPY1 | 1/20 | 0.33 |
| ▸ | GABRP | O00591 | 1/20 | 0.33 |
| ▸ | GABRD | O14764 | 1/20 | 0.33 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.33 |
| ▸ | GABBR2 | O75899 | 1/20 | 0.33 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.33 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1263484 | 0.97 | — | — | |
| Ammonia Solution, Strong SCHEMBL20920090 | 0.94 | — | — | |
| Hydrochloric Acid SCHEMBL28664938 | 0.94 | — | — | |
| SCHEMBL20254028 | 0.81 | ALDH1A1 (0.39) | CTHLMNAIDO1GLRA1SLC6A9 | |
| SCHEMBL29463188 | 0.81 | ALDH1A1 (0.39) | CTHLMNAIDO1GLRA1SLC6A9 | |
| SCHEMBL4163229 | 0.81 | CTH (0.37) | CTHLMNAIDO1THRBCYP1A2 | |
| Bicarbonate SCHEMBL177964 | 0.81 | CA1 (0.39) | LMNATSHRALDH1A1 | |
| SCHEMBL2490055 | 0.80 | — | — | |
| Ethylenediamine SCHEMBL7190420 | 0.80 | TSHR (0.42) | CTHLMNAGLRA1SLC6A9OR51E2 | |
| SCHEMBL5997537 | 0.79 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-109021281-B | Composite foaming agent and application thereof in preparation of polyurethane foam | 广西斯佰祥科技产业有限公司 | 2021-11-26 | — | — | CN | claimed |
| CN-109021280-B | Preparation method of polyurethane foam and polyurethane foam | 淮北市星光新材料科技有限公司 | 2021-11-12 | — | — | CN | claimed |
| CN-109021281-B | Composite foaming agent and application thereof in preparation of polyurethane foam | 广西斯佰祥科技产业有限公司 | 2021-11-26 | — | — | CN | disclosed |
| CN-109021281-B | Composite foaming agent and application thereof in preparation of polyurethane foam | 广西斯佰祥科技产业有限公司 | 2021-11-26 | — | — | CN | disclosed |
| CN-109021280-B | Preparation method of polyurethane foam and polyurethane foam | 淮北市星光新材料科技有限公司 | 2021-11-12 | — | — | CN | disclosed |