SCHEMBL28648702

SCHEMBL28648702

CNc1ccc(C)cc1.N#CCC#N

nearest known ligand 0.44

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 3/20 0.44
CYP2A6 P11509 1/20 0.44
MAPT P10636 2/20 0.44
HTT P42858 3/20 0.38
NPC1 O15118 1/20 0.38
RAB9A P51151 1/20 0.38
SMN1; SMN2 Q16637 1/20 0.38
POLB P06746 2/20 0.38
TSHR P16473 1/20 0.37
HPGD P15428 1/20 0.37
APP P05067 1/20 0.36
LMNA P02545 2/20 0.36
KDM4E B2RXH2 1/20 0.36
MEN1 O00255 1/20 0.35
KMT2A Q03164 1/20 0.35
GLA P06280 1/20 0.35
GAA P10253 1/20 0.35
DHODH Q02127 1/20 0.35
ACHE P22303 1/20 0.35
TDP1 Q9NUW8 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Acetonitrile SCHEMBL6675224 0.84 ALDH1A1 (0.48) ALDH1A1CYP2A6MAPTTSHRHPGD
SCHEMBL28650478 0.81 MAPT (0.42) ALDH1A1MAPTSMN1; SMN2TSHRHPGD
SCHEMBL28659480 0.81 ALDH1A1 (0.42) ALDH1A1MAPTNPC1RAB9ASMN1; SMN2
SCHEMBL28653668 0.81 ALDH1A1 (0.42) ALDH1A1MAPTHTTNPC1RAB9A
SCHEMBL44533 0.81
SCHEMBL28640842 0.80 TSHR (0.64) ALDH1A1MAPTHTTSMN1; SMN2POLB
Hydrochloric Acid SCHEMBL2866389 0.78 MAPT (0.50) ALDH1A1MAPTPOLBTSHRHPGD
SCHEMBL28663846 0.78 GAA (0.56) ALDH1A1MAPTHTTNPC1RAB9A
SCHEMBL28649867 0.77 LOXL2 (0.61) ALDH1A1CYP2A6MAPTHTTNPC1
SCHEMBL18951277 0.75 MAPT (0.48) ALDH1A1CYP2A6MAPTHTTNPC1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-113683550-A Synthesis method of N- (cyano (2-cyano substituted phenyl) methyl) substituted tertiary amine 兰州大学 2021-11-23 CN disclosed