SCHEMBL28650478

SCHEMBL28650478

CNc1ccc(Br)cc1.N#CCC#N

nearest known ligand 0.42

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAPT P10636 3/20 0.42
ALDH1A1 P00352 1/20 0.42
IDO1 P14902 1/20 0.38
GAA P10253 3/20 0.37
CYP2D6 P10635 1/20 0.37
CYP2C9 P11712 1/20 0.37
MEN1 O00255 1/20 0.36
KMT2A Q03164 1/20 0.36
TAAR1 Q96RJ0 1/20 0.36
LMNA P02545 1/20 0.36
TSHR P16473 1/20 0.36
APP P05067 2/20 0.35
MAOA P21397 1/20 0.35
MAOB P27338 1/20 0.35
SMN1; SMN2 Q16637 1/20 0.35
EGFR P00533 1/20 0.35
ERBB2 P04626 1/20 0.35
HPGD P15428 1/20 0.34
FPR3 P25089 1/20 0.34
FPR2 P25090 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Acetonitrile SCHEMBL6671506 0.85 ALDH1A1 (0.47) MAPTALDH1A1IDO1GAACYP2D6
SCHEMBL467157 0.82
SCHEMBL28648702 0.81 ALDH1A1 (0.44) MAPTALDH1A1GAAMEN1KMT2A
Hydrochloric Acid SCHEMBL27724865 0.79 TSHR (0.48) MAPTALDH1A1MEN1KMT2ATAAR1
SCHEMBL28653668 0.79 ALDH1A1 (0.42) MAPTALDH1A1GAACYP2D6CYP2C9
SCHEMBL28659480 0.79 ALDH1A1 (0.42) MAPTALDH1A1GAATAAR1LMNA
SCHEMBL28640842 0.78 TSHR (0.64) MAPTALDH1A1GAAMEN1KMT2A
SCHEMBL28663846 0.76 GAA (0.56) MAPTALDH1A1GAAAPPSMN1; SMN2
SCHEMBL9654351 0.75 KIF11 (0.52) ALDH1A1MEN1KMT2ATSHRAPP
SCHEMBL13192623 0.74 CA2 (0.46) MAPTALDH1A1GAACYP2D6CYP2C9

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-113683550-A Synthesis method of N- (cyano (2-cyano substituted phenyl) methyl) substituted tertiary amine 兰州大学 2021-11-23 CN disclosed