SCHEMBL28651963

SCHEMBL28651963

Cc1cc(F)ccc1CCNC(=O)c1cc(Cl)nnc1Cl

nearest known ligand 0.42

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 5/20 0.42
RAB9A P51151 2/20 0.42
L3MBTL1 Q9Y468 1/20 0.42
P2RX7 Q99572 5/20 0.41
IL1B P01584 1/20 0.41
MAPT P10636 2/20 0.40
TP53 P04637 1/20 0.40
POLB P06746 1/20 0.40
TAAR1 Q96RJ0 1/20 0.40
CNR1 P21554 3/20 0.39
CNR2 P34972 2/20 0.39
NR3C2 P08235 1/20 0.39
NPC1 O15118 1/20 0.39
CASP1 P29466 1/20 0.38
LMNA P02545 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL31683860 1.00 ALDH1A1 (0.42) ALDH1A1RAB9AL3MBTL1P2RX7IL1B
SCHEMBL31683864 0.84 TP53 (0.49) ALDH1A1RAB9AL3MBTL1P2RX7MAPT
SCHEMBL28631162 0.84 TP53 (0.49) ALDH1A1RAB9AL3MBTL1P2RX7MAPT
SCHEMBL28635932 0.82 NPC1 (0.49) ALDH1A1RAB9AMAPTCNR1CNR2
SCHEMBL31683863 0.82 NPC1 (0.49) ALDH1A1RAB9AMAPTCNR1CNR2
SCHEMBL31683861 0.80 NPC1 (0.53) ALDH1A1RAB9AL3MBTL1P2RX7CNR1
SCHEMBL28635599 0.80 NPC1 (0.53) ALDH1A1RAB9AL3MBTL1P2RX7CNR1
SCHEMBL31683854 0.79 CNR1 (0.52) ALDH1A1RAB9APOLBTAAR1CNR1
SCHEMBL28636200 0.79 CNR1 (0.52) ALDH1A1RAB9APOLBTAAR1CNR1
SCHEMBL31683857 0.78 CASP1 (0.57) ALDH1A1L3MBTL1P2RX7MAPTPOLB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-113490663-A Pyridazine (thio) amides as fungicidal compounds 拜耳公司 2021-10-08 CN disclosed