Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CES2 | O00748 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.38 |
| ▸ | HSD17B1 | P14061 | 1/20 | 0.37 |
| ▸ | HSD17B2 | P37059 | 1/20 | 0.37 |
| ▸ | RORC | P51449 | 1/20 | 0.37 |
| ▸ | RORB | Q92753 | 1/20 | 0.37 |
| ▸ | KDR | P35968 | 1/20 | 0.37 |
| ▸ | KIF11 | P52732 | 2/20 | 0.36 |
| ▸ | HTR3E | A5X5Y0 | 1/20 | 0.36 |
| ▸ | HTR3B | O95264 | 1/20 | 0.36 |
| ▸ | HTR3A | P46098 | 1/20 | 0.36 |
| ▸ | HTR3D | Q70Z44 | 1/20 | 0.36 |
| ▸ | HTR3C | Q8WXA8 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | PKM | P14618 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27653563 | 0.87 | P2RX1 (0.41) | CES2MEN1KMT2AALDH1A1RORC | |
| SCHEMBL5606524 | 0.86 | CES2 (0.50) | CES2MEN1KMT2AALDH1A1KIF11 | |
| SCHEMBL3674538 | 0.85 | CES2 (0.40) | CES2MEN1KMT2AALDH1A1RORC | |
| SCHEMBL28217598 | 0.82 | PTGIR (0.46) | CES2MEN1KMT2AKIF11HTR3E | |
| SCHEMBL7609002 | 0.78 | SRD5A2 (0.55) | CES2MEN1KMT2AALDH1A1HTT | |
| SCHEMBL7739130 | 0.78 | CES2 (0.50) | CES2MEN1KMT2AALDH1A1LMNA | |
| SCHEMBL4246399 | 0.77 | HTR3E (0.49) | MEN1KMT2AKDRHTR3EHTR3B | |
| SCHEMBL7738559 | 0.77 | SRD5A2 (0.52) | CES2MEN1KMT2AALDH1A1LMNA | |
| SCHEMBL28217604 | 0.77 | GRM4 (0.44) | MEN1KMT2AALDH1A1KDRHTR3E | |
| SCHEMBL1942998 | 0.76 | POLQ (0.41) | KMT2AALDH1A1KDRLMNAHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-113574055-A | PCSK9 inhibitors and methods of use thereof | 阿斯利康(瑞典)有限公司 | 2021-10-29 | — | — | CN | disclosed |