Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PCNA | P12004 | 3/20 | 0.66 |
| ▸ | THRA | P10827 | 8/20 | 0.63 |
| ▸ | THRB | P10828 | 8/20 | 0.63 |
| ▸ | POLB | P06746 | 1/20 | 0.63 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.63 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.63 |
| ▸ | FFAR1 | O14842 | 8/20 | 0.61 |
| ▸ | FFAR4 | Q5NUL3 | 4/20 | 0.55 |
| ▸ | ESR1 | P03372 | 1/20 | 0.49 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.49 |
| ▸ | PGR | P06401 | 1/20 | 0.49 |
| ▸ | NR3C2 | P08235 | 1/20 | 0.49 |
| ▸ | AR | P10275 | 1/20 | 0.49 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.49 |
| ▸ | ITGAV | P06756 | 1/20 | 0.49 |
| ▸ | RXRA | P19793 | 1/20 | 0.49 |
| ▸ | PPARG | P37231 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4269700 | 0.92 | FFAR1 (0.70) | PCNATHRATHRBPOLBMAPK1 | |
| SCHEMBL2871768 | 0.88 | FFAR1 (0.73) | PCNATHRATHRBPOLBMAPK1 | |
| SCHEMBL4280680 | 0.82 | FFAR1 (0.60) | PCNATHRATHRBPOLBMAPK1 | |
| SCHEMBL4271148 | 0.82 | THRA (0.57) | PCNATHRATHRBPOLBMAPK1 | |
| SCHEMBL4238467 | 0.81 | THRB (0.73) | PCNATHRATHRBPOLBMAPK1 | |
| SCHEMBL16425259 | 0.81 | PCNA (0.68) | PCNATHRATHRBPOLBMAPK1 | |
| SCHEMBL6731598 | 0.80 | THRA (0.56) | PCNATHRATHRBPOLBMAPK1 | |
| SCHEMBL7042106 | 0.80 | FFAR1 (0.54) | PCNATHRATHRBMAPK1FFAR1 | |
| SCHEMBL4266556 | 0.80 | FFAR1 (0.63) | PCNATHRATHRBPOLBMAPK1 | |
| 3,5-Diiodothyropropionic Acid SCHEMBL1501771 | 0.80 | PCNA (1.00) | PCNATHRATHRBPOLBMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080161351-A1 | Linked biaryl compounds | TULARIK INC. | 2008-07-03 | — | — | US | claimed |
| US-20030149108-A1 | Linked biaryl compounds | TULARIK INC. | 2003-08-07 | — | — | US | claimed |
| US-7645779-B2 | Linked biaryl compounds | AMGEN INC. (US) | 2010-01-12 | — | — | US | disclosed |
| US-20080161351-A1 | Linked biaryl compounds | TULARIK INC. | 2008-07-03 | — | — | US | disclosed |
| EP-1435946-A4 | LINKED BIARYL COMPOUNDS | TULARIK INC (US) | 2006-02-01 | — | — | EP | disclosed |
| US-6869975-B2 | Linked biaryl compounds | TULARIK INC. (US) | 2005-03-22 | — | — | US | disclosed |
| EP-1435946-A2 | LINKED BIARYL COMPOUNDS | Tularik Inc. (US) | 2004-07-14 | — | — | EP | disclosed |
| US-20030149108-A1 | Linked biaryl compounds | TULARIK INC. | 2003-08-07 | — | — | US | disclosed |
| WO-2003024395-A2 | LINKED BIARYL COMPOUNDS | TULARIK INC. (US) | 2003-03-27 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030149108-A1 | Linked biaryl compounds | SREBF2, SREBF1, ACACB | PCNA 272/4885THRA 3174/4885THRB 1497/4885 |
| US-20080161351-A1 | Linked biaryl compounds | SREBF2, SREBF1, ACACB | PCNA 272/4885THRA 3174/4885THRB 1497/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.