Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.51 |
| ▸ | TSHR | P16473 | 2/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 7/20 | 0.47 |
| ▸ | MEN1 | O00255 | 6/20 | 0.47 |
| ▸ | LMNA | P02545 | 4/20 | 0.47 |
| ▸ | APOBEC3A | P31941 | 2/20 | 0.47 |
| ▸ | APOBEC3G | Q9HC16 | 2/20 | 0.47 |
| ▸ | MAPT | P10636 | 3/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | CLK1 | P49759 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 2/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | PPARG | P37231 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28659024 | 0.86 | ALDH1A1 (0.48) | ALDH1A1SMN1; SMN2TSHRKMT2AMEN1 | |
| SCHEMBL28673832 | 0.86 | MEN1 (0.53) | ALDH1A1SMN1; SMN2TSHRKMT2AMEN1 | |
| SCHEMBL28669727 | 0.86 | MEN1 (0.48) | ALDH1A1SMN1; SMN2TSHRKMT2AMEN1 | |
| SCHEMBL28660616 | 0.85 | HPGD (0.46) | ALDH1A1SMN1; SMN2TSHRKMT2AMEN1 | |
| SCHEMBL28664789 | 0.84 | HPGD (0.45) | ALDH1A1SMN1; SMN2TSHRKMT2AMEN1 | |
| SCHEMBL21952024 | 0.83 | TSHR (0.61) | ALDH1A1SMN1; SMN2TSHRKMT2AMEN1 | |
| SCHEMBL21952043 | 0.76 | ALDH1A1 (0.64) | ALDH1A1SMN1; SMN2TSHRKMT2AMEN1 | |
| SCHEMBL28929896 | 0.76 | ALDH1A1 (0.53) | ALDH1A1SMN1; SMN2TSHRKMT2AMEN1 | |
| SCHEMBL25610429 | 0.76 | TSHR (0.58) | ALDH1A1SMN1; SMN2TSHRKMT2AMEN1 | |
| SCHEMBL28661287 | 0.73 | ALDH1A1 (0.47) | ALDH1A1SMN1; SMN2TSHRKMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115768422-A | Ubiquitin ligase inhibitors for the treatment of cancer | 诺沃亚桑托斯教授基金会 | 2023-03-07 | — | — | CN | disclosed |
| CN-113677340-A | Compounds that selectively and efficiently inhibit Hakai-mediated ubiquitination as anti-cancer agents | 诺沃亚桑托斯教授基金会 | 2021-11-19 | — | — | CN | disclosed |