Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 9/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 9/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.48 |
| ▸ | ATM | Q13315 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | ALPL | P05186 | 1/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | ALPG | P10696 | 1/20 | 0.47 |
| ▸ | THRB | P10828 | 1/20 | 0.47 |
| ▸ | APEX1 | P27695 | 1/20 | 0.47 |
| ▸ | RECQL | P46063 | 1/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.47 |
| ▸ | HPGD | P15428 | 2/20 | 0.47 |
| ▸ | TSHR | P16473 | 3/20 | 0.45 |
| ▸ | PPARG | P37231 | 1/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28659024 | 0.89 | ALDH1A1 (0.48) | MEN1KMT2AMAPK1ATMALDH1A1 | |
| SCHEMBL28673832 | 0.89 | MEN1 (0.53) | MEN1KMT2AMAPK1ATMALDH1A1 | |
| SCHEMBL28660616 | 0.88 | HPGD (0.46) | MEN1KMT2AMAPK1ATMALDH1A1 | |
| SCHEMBL28664789 | 0.87 | HPGD (0.45) | MEN1KMT2AMAPK1ATMALDH1A1 | |
| SCHEMBL28655707 | 0.86 | ALDH1A1 (0.51) | MEN1KMT2AMAPK1ALDH1A1HPGD | |
| SCHEMBL21952051 | 0.82 | TSHR (0.65) | MEN1KMT2AMAPK1ATMALDH1A1 | |
| SCHEMBL28669731 | 0.76 | MAPK1 (0.60) | MEN1KMT2AMAPK1ATMALDH1A1 | |
| SCHEMBL21952015 | 0.76 | TSHR (0.70) | MEN1KMT2AMAPK1ALDH1A1TDP1 | |
| SCHEMBL30278759 | 0.76 | TSHR (0.70) | MEN1KMT2AMAPK1ALDH1A1TDP1 | |
| SCHEMBL21952008 | 0.75 | TSHR (0.42) | MEN1KMT2AMAPK1ATMALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115768422-A | Ubiquitin ligase inhibitors for the treatment of cancer | 诺沃亚桑托斯教授基金会 | 2023-03-07 | — | — | CN | disclosed |
| CN-113677340-A | Compounds that selectively and efficiently inhibit Hakai-mediated ubiquitination as anti-cancer agents | 诺沃亚桑托斯教授基金会 | 2021-11-19 | — | — | CN | disclosed |