Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | SCN4A | P35499 | 1/20 | 0.34 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.34 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 2/20 | 0.33 |
| ▸ | POLB | P06746 | 2/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | PARP1 | P09874 | 1/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
| ▸ | RECQL | P46063 | 1/20 | 0.33 |
| ▸ | BLM | P54132 | 1/20 | 0.33 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | ATM | Q13315 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 2/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Urea SCHEMBL28100950 | 0.95 | TSHR (0.35) | TSHRLMNAMAPK1SCN4ASCN5A | |
| Bicarbonate SCHEMBL28655831 | 0.93 | MEN1 (0.33) | CYP2C9MAPTPOLBMEN1KMT2A | |
| Propionic Acid SCHEMBL19423436 | 0.92 | CES2 (0.32) | TSHRLMNAMAPK1SCN4ASCN5A | |
| SCHEMBL3201327 | 0.89 | MAPT (0.36) | MAPTPARP1MEN1KMT2AKDM4E | |
| Benzene SCHEMBL28211936 | 0.89 | MAPT (0.36) | MAPTPARP1MEN1KMT2AKDM4E | |
| Acetone SCHEMBL25211182 | 0.87 | GAA (0.33) | LMNAMAPTMEN1KMT2AKDM4E | |
| SCHEMBL8924 | 0.87 | MAPT (0.37) | MAPTPARP1MEN1KMT2AKDM4E | |
| SCHEMBL29804885 | 0.87 | MAPT (0.37) | MAPTPARP1MEN1KMT2AKDM4E | |
| SCHEMBL3662203 | 0.87 | MAPT (0.37) | MAPTPARP1MEN1KMT2AKDM4E | |
| SCHEMBL16341187 | 0.87 | MAPT (0.37) | MAPTPARP1MEN1KMT2AKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 16 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10745364-B2 | Tetrahydronaphthyridine, benzoxazine, aza-benzoxazine and related bicyclic compounds for inhibition of RORgamma activity and the treatment of disease | LYCERA CORPORATION (US) | 2020-08-18 | — | — | US | disclosed |
| US-20190292159-A1 | TETRAHYDRONAPHTHYRIDINE, BENZOXAZINE, AZA-BENZOXAZINE AND RELATED BICYCLIC COMPOUNDS FOR INHIBITION OF RORgamma ACTIVITY AND THE TREATMENT OF DISEASE | MERCK SHARP & DOHME LLC | 2019-09-26 | — | — | US | disclosed |
| US-10221146-B2 | Tetrahydronaphthyridine, benzoxazine, aza-benzoxazine and related bicyclic compounds for inhibition of RORgamma activity and the treatment of disease | LYCERA CORPORATION (US) | 2019-03-05 | — | — | US | disclosed |
| US-20180030005-A1 | TETRAHYDRONAPHTHYRIDINE, BENZOXAZINE, AZA-BENZOXAZINE AND RELATED BICYCLIC COMPOUNDS FOR INHIBITION OF RORgamma ACTIVITY AND THE TREATMENT OF DISEASE | MERCK SHARP & DOHME LLC | 2018-02-01 | — | — | US | disclosed |
| US-9809561-B2 | Tetrahydronaphthyridine, benzoxazine, aza-benzoxazine and related bicyclic compounds for inhibition of RORgamma activity and the treatment of disease | MERCK SHARP & DOHME CORP. (US) | 2017-11-07 | — | — | US | disclosed |
| US-20160304476-A1 | TETRAHYDRONAPHTHYRIDINE, BENZOXAZINE, AZA-BENZOXAZINE AND RELATED BICYCLIC COMPOUNDS FOR INHIBITION OF RORgamma ACTIVITY AND THE TREATMENT OF DISEASE | MERCK SHARP & DOHME LLC | 2016-10-20 | — | — | US | disclosed |
| WO-2015095795-A1 | TETRAHYDRONAPHTHYRIDINE, BENZOXAZINE, AZA-BENZOXAZINE, AND RELATED BICYCLIC COMPOUNDS FOR INHIBITION OF RORgamma ACTIVITY AND THE TREATMENT OF DISEASE | MERCK SHARP & DOHME CORP. (US) | 2015-06-25 | — | — | WO | disclosed |
| CN-101646562-B | Prepreg laminates | HENKEL CORP | 2012-12-05 | — | — | CN | disclosed |
| CN-101360788-B | Curable compositions | HENKEL CORP | 2012-10-10 | — | — | CN | disclosed |
| CN-101360788-A | Curable compositions | HENKEL CORP (US) | 2009-02-04 | — | — | CN | disclosed |
| EP-1438073-A2 | POLYOXYALKYLENES CONJUGATES AS ENZYME INHIBITORS | THE PROCTER & GAMBLE COMPANY (US) | 2004-07-21 | — | — | EP | disclosed |
| EP-1212097-A2 | ENZYME INHIBITORS | THE PROCTER & GAMBLE COMPANY (US) | 2002-06-12 | — | — | EP | disclosed |
| EP-1212098-A2 | ENZYME INHIBITORS | THE PROCTER & GAMBLE COMPANY (US) | 2002-06-12 | — | — | EP | disclosed |
| WO-2001017564-A2 | ENZYME INHIBITORS | THE PROCTER & GAMBLE COMPANY (US) | 2001-03-15 | — | — | WO | disclosed |
| WO-2001017565-A2 | POLYOXYALKYLENES CONJUGATES AS ENZYME INHIBITORS | THE PROCTER & GAMBLE COMPANY (US) | 2001-03-15 | — | — | WO | disclosed |
| WO-2001018181-A2 | ENZYME INHIBITORS | THE PROCTER & GAMBLE COMPANY (US) | 2001-03-15 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180030005-A1 | TETRAHYDRONAPHTHYRIDINE, BENZOXAZINE, AZA-BENZOXAZINE AND RELATED BICYCLIC COMPOUNDS FOR INHIBITION OF RORgamma ACTIVITY AND THE TREATMENT OF DISEASE | RORB, RORA, RORC | TSHR 172/4885LMNA 3604/4885MAPK1 4228/4885 |
| US-10745364-B2 | Tetrahydronaphthyridine, benzoxazine, aza-benzoxazine and related bicyclic compounds for inhibition of RORgamma activity and the treatment of disease | RORB, RORA, RORC | TSHR 172/4885LMNA 3604/4885MAPK1 4228/4885 |
| US-20190292159-A1 | TETRAHYDRONAPHTHYRIDINE, BENZOXAZINE, AZA-BENZOXAZINE AND RELATED BICYCLIC COMPOUNDS FOR INHIBITION OF RORgamma ACTIVITY AND THE TREATMENT OF DISEASE | RORB, RORA, RORC | TSHR 172/4885LMNA 3604/4885MAPK1 4228/4885 |
| US-20160304476-A1 | TETRAHYDRONAPHTHYRIDINE, BENZOXAZINE, AZA-BENZOXAZINE AND RELATED BICYCLIC COMPOUNDS FOR INHIBITION OF RORgamma ACTIVITY AND THE TREATMENT OF DISEASE | RORB, RORA, RORC | TSHR 172/4885LMNA 3604/4885MAPK1 4228/4885 |
| US-10221146-B2 | Tetrahydronaphthyridine, benzoxazine, aza-benzoxazine and related bicyclic compounds for inhibition of RORgamma activity and the treatment of disease | RORB, RORA, RORC | TSHR 154/4885LMNA 3553/4885MAPK1 4230/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.