Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LOXL2 | Q9Y4K0 | 9/20 | 0.52 |
| ▸ | MAP4K3 | Q8IVH8 | 3/20 | 0.37 |
| ▸ | FGFR1 | P11362 | 5/20 | 0.34 |
| ▸ | FGFR2 | P21802 | 5/20 | 0.34 |
| ▸ | FGFR3 | P22607 | 5/20 | 0.34 |
| ▸ | MAP3K7 | O43318 | 1/20 | 0.34 |
| ▸ | TAB1 | Q15750 | 1/20 | 0.34 |
| ▸ | LOXL3 | P58215 | 1/20 | 0.34 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.34 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.34 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.33 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.33 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.33 |
| ▸ | PI4KA | P42356 | 1/20 | 0.33 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.33 |
| ▸ | PI4KB | Q9UBF8 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19259726 | 0.89 | LOXL2 (0.49) | LOXL2FGFR1FGFR2FGFR3LOXL3 | |
| SCHEMBL28639354 | 0.86 | LOXL2 (0.51) | LOXL2FGFR1FGFR2FGFR3LOXL3 | |
| SCHEMBL28660990 | 0.85 | LOXL2 (0.51) | LOXL2FGFR1LOXL3 | |
| SCHEMBL19259611 | 0.84 | LOXL2 (0.50) | LOXL2MAP4K3FGFR1FGFR2FGFR3 | |
| SCHEMBL28657644 | 0.82 | LOXL2 (0.78) | LOXL2LOXL3KCNH2 | |
| SCHEMBL19274480 | 0.81 | LOXL2 (0.47) | LOXL2MAP4K3FGFR1FGFR2FGFR3 | |
| SCHEMBL29971042 | 0.81 | LOXL2 (0.47) | LOXL2MAP4K3FGFR1FGFR2FGFR3 | |
| SCHEMBL28639341 | 0.77 | ICAM1 (0.35) | LOXL2LOXL3 | |
| SCHEMBL19259767 | 0.77 | LOXL2 (0.48) | LOXL2LOXL3KCNH2 | |
| SCHEMBL28638875 | 0.75 | LOXL2 (0.46) | LOXL2LOXL3PIK3CDPIK3CAPIK3CB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-109311839-B | Methylamine derivatives as lysyl oxidase inhibitors for the treatment of cancer | 癌症研究协会皇家癌症医院 | 2021-11-02 | — | — | CN | disclosed |