Known targets — ChEMBL curated mechanism
ADRA2AADRA2BADRA2CADRB2AGTR1AVPR1AAVPR1BAVPR2BDKRB2CALCRCHRNA3CHRNB4ESR1ESR2GHSRGNRHRGSC1HSPA8MALT1MC1RMC4RNOS1NOS2NOS3OPRK1OXTRRAMP1RAMP2RAMP3SCN5ASSTR1SSTR2SSTR3SSTR4SSTR5dacAdacBdacCfolPftsImrcAmrcBmrdArplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Acetic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOS3 known ✓ | P29474 | 1/20 | 0.32 |
| ▸ | NOS1 known ✓ | P29475 | 1/20 | 0.32 |
| ▸ | NOS2 known ✓ | P35228 | 1/20 | 0.32 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.72 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.55 |
| ▸ | MAPT | P10636 | 3/20 | 0.38 |
| ▸ | USP2 | O75604 | 2/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
| ▸ | LPAR5 | Q9H1C0 | 1/20 | 0.34 |
| ▸ | PLA2G2C | Q5R387 | 3/20 | 0.33 |
| ▸ | SPHK1 | Q9NYA1 | 1/20 | 0.33 |
| ▸ | ALPL | P05186 | 1/20 | 0.32 |
| ▸ | ALPI | P09923 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Acetic Acid SCHEMBL3099063 | 0.96 | HSD17B10 (0.78) | HSD17B10TDP1MAPTUSP2KDM4E | |
| Acetic Acid Methyl Ester SCHEMBL28347932 | 0.88 | HSD17B10 (0.72) | HSD17B10TDP1MAPTUSP2KDM4E | |
| Propionic Acid SCHEMBL3286165 | 0.86 | HSD17B10 (0.75) | HSD17B10TDP1MAPTUSP2KDM4E | |
| SCHEMBL9637969 | 0.85 | — | — | |
| SCHEMBL34792 | 0.85 | — | — | |
| SCHEMBL17164541 | 0.85 | — | — | |
| SCHEMBL21356623 | 0.85 | HSD17B10 (1.00) | HSD17B10TDP1MAPTUSP2KDM4E | |
| Methacrylic Acid SCHEMBL26637849 | 0.85 | HSD17B10 (0.67) | HSD17B10TDP1MAPTUSP2KDM4E | |
| Acetic Acid SCHEMBL3249565 | 0.84 | HSD17B10 (0.59) | HSD17B10TDP1MAPTUSP2KDM4E | |
| SCHEMBL8930268 | 0.83 | HSD17B10 (0.86) | HSD17B10TDP1MAPTUSP2KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-109817513-B | Method of manufacturing semiconductor device and method of cleaning substrate | 台湾积体电路制造股份有限公司 | 2021-06-01 | — | — | CN | disclosed |