Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 6/20 | 0.51 |
| ▸ | MEN1 | O00255 | 5/20 | 0.51 |
| ▸ | HPGD | P15428 | 2/20 | 0.50 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.46 |
| ▸ | PPARG | P37231 | 1/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.44 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | ATM | Q13315 | 2/20 | 0.41 |
| ▸ | RECQL | P46063 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | DHODH | Q02127 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21952098 | 0.84 | MAPT (0.56) | KMT2AMEN1HPGDNPSR1ALDH1A1 | |
| SCHEMBL24019587 | 0.83 | ALOX5 (0.39) | KMT2AMEN1ALDH1A1MAPK1HSD17B10 | |
| SCHEMBL28663116 | 0.83 | TP53 (0.36) | KMT2AMEN1HPGDNPSR1ALDH1A1 | |
| SCHEMBL28670742 | 0.83 | HPGD (0.50) | KMT2AMEN1HPGDNPSR1ALDH1A1 | |
| SCHEMBL28655968 | 0.83 | KMT2A (0.58) | KMT2AMEN1HPGDNPSR1ALDH1A1 | |
| SCHEMBL28669731 | 0.83 | MAPK1 (0.60) | KMT2AMEN1HPGDNPSR1ALDH1A1 | |
| SCHEMBL28660621 | 0.82 | SMN1; SMN2 (0.58) | KMT2AMEN1HPGDNPSR1ALDH1A1 | |
| SCHEMBL28664794 | 0.82 | HPGD (0.49) | KMT2AMEN1HPGDNPSR1ALDH1A1 | |
| SCHEMBL28676731 | 0.80 | HPGD (0.51) | KMT2AMEN1HPGDNPSR1ALDH1A1 | |
| SCHEMBL24019625 | 0.79 | MEN1 (0.53) | KMT2AMEN1HPGDNPSR1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115768422-A | Ubiquitin ligase inhibitors for the treatment of cancer | 诺沃亚桑托斯教授基金会 | 2023-03-07 | — | — | CN | disclosed |
| CN-113677340-A | Compounds that selectively and efficiently inhibit Hakai-mediated ubiquitination as anti-cancer agents | 诺沃亚桑托斯教授基金会 | 2021-11-19 | — | — | CN | disclosed |