Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX5 | P09917 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 3/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | ESR1 | P03372 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21952011 | 0.85 | LMNA (0.47) | ALOX5ALDH1A1KMT2ALMNAHSD17B10 | |
| SCHEMBL28663116 | 0.84 | TP53 (0.36) | ALDH1A1KMT2ALMNATP53HSD17B10 | |
| SCHEMBL28659325 | 0.83 | KMT2A (0.51) | ALDH1A1KMT2ATP53HSD17B10MEN1 | |
| SCHEMBL31396222 | 0.75 | ALPL (0.47) | ALDH1A1KMT2ALMNAHSD17B10MEN1 | |
| SCHEMBL28673736 | 0.73 | HPGD (0.53) | ALDH1A1KMT2ATP53MEN1TSHR | |
| SCHEMBL28670742 | 0.72 | HPGD (0.50) | ALDH1A1KMT2ATP53MEN1TSHR | |
| SCHEMBL28664794 | 0.71 | HPGD (0.49) | ALDH1A1KMT2AMEN1POLBMAPK1 | |
| SCHEMBL21952069 | 0.70 | ALDH1A1 (0.44) | ALDH1A1KMT2ALMNATP53HSD17B10 | |
| SCHEMBL29798375 | 0.70 | ALDH1A1 (0.44) | ALDH1A1KMT2ALMNATP53HSD17B10 | |
| SCHEMBL28678932 | 0.70 | TSHR (0.53) | ALOX5ALDH1A1KMT2ALMNATP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115768422-A | Ubiquitin ligase inhibitors for the treatment of cancer | 诺沃亚桑托斯教授基金会 | 2023-03-07 | — | — | CN | disclosed |
| CN-113677340-A | Compounds that selectively and efficiently inhibit Hakai-mediated ubiquitination as anti-cancer agents | 诺沃亚桑托斯教授基金会 | 2021-11-19 | — | — | CN | disclosed |
| EP-3909577-A1 | UBIQUITIN-LIGASE INHIBITORS FOR THE TREATMENT OF CANCER | Fundación Profesor Novoa Santos (ES) | 2021-11-17 | — | — | EP | disclosed |