Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.48 |
| ▸ | RAB9A | P51151 | 2/20 | 0.48 |
| ▸ | GAA | P10253 | 1/20 | 0.48 |
| ▸ | XDH | P47989 | 6/20 | 0.48 |
| ▸ | POLB | P06746 | 3/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | ABCC4 | O15439 | 1/20 | 0.43 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.43 |
| ▸ | PGR | P06401 | 1/20 | 0.43 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.43 |
| ▸ | PDE4A | P27815 | 1/20 | 0.43 |
| ▸ | BLVRB | P30043 | 1/20 | 0.43 |
| ▸ | TARBP2 | Q15633 | 1/20 | 0.43 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.43 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | USP2 | O75604 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28672534 | 0.85 | SMN1; SMN2 (0.63) | SMN1; SMN2KDM4ERAB9AGAAXDH | |
| SCHEMBL28660397 | 0.79 | SMN1; SMN2 (0.56) | SMN1; SMN2KDM4ERAB9AGAAXDH | |
| SCHEMBL10049086 | 0.78 | SMN1; SMN2 (0.60) | SMN1; SMN2KDM4ERAB9AGAAPOLB | |
| SCHEMBL28680613 | 0.77 | KDM4E (0.47) | SMN1; SMN2KDM4ERAB9AGAAXDH | |
| SCHEMBL30307094 | 0.76 | SMN1; SMN2 (0.54) | SMN1; SMN2KDM4ERAB9AGAAXDH | |
| SCHEMBL28675601 | 0.76 | KDM4E (0.47) | SMN1; SMN2KDM4ERAB9AGAAXDH | |
| SCHEMBL28929128 | 0.75 | XDH (0.48) | SMN1; SMN2KDM4ERAB9AGAAXDH | |
| SCHEMBL289681 | 0.73 | KDM4E (0.56) | SMN1; SMN2KDM4ERAB9AGAAPOLB | |
| SCHEMBL5899840 | 0.69 | RAB9A (0.70) | SMN1; SMN2KDM4ERAB9AGAAXDH | |
| SCHEMBL2185636 | 0.69 | XDH (0.67) | SMN1; SMN2KDM4ERAB9AGAAXDH |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-113024534-B | 2-pyridylthiazole derivatives and use thereof | 武汉光谷亚太医药研究院有限公司 | 2023-03-21 | — | — | CN | claimed |
| CN-113024534-A | 2-pyridylthiazole derivatives and use thereof | 武汉光谷亚太医药研究院有限公司 | 2021-06-25 | — | — | CN | claimed |
| CN-113024534-B | 2-pyridylthiazole derivatives and use thereof | 武汉光谷亚太医药研究院有限公司 | 2023-03-21 | — | — | CN | disclosed |
| CN-113024534-A | 2-pyridylthiazole derivatives and use thereof | 武汉光谷亚太医药研究院有限公司 | 2021-06-25 | — | — | CN | disclosed |