Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TTR | P02766 | 1/20 | 0.39 |
| ▸ | MAP3K5 | Q99683 | 9/20 | 0.38 |
| ▸ | HCAR1 | Q9BXC0 | 1/20 | 0.37 |
| ▸ | P2RY14 | Q15391 | 1/20 | 0.35 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.35 |
| ▸ | KDM4C | Q9H3R0 | 2/20 | 0.34 |
| ▸ | KDM4A | O75164 | 1/20 | 0.34 |
| ▸ | ABL1 | P00519 | 2/20 | 0.34 |
| ▸ | KDM2B | Q8NHM5 | 1/20 | 0.34 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.34 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.33 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.33 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28658710 | 0.88 | MAP4K4 (0.39) | MAP3K5ABL1RIPK2 | |
| SCHEMBL28643386 | 0.88 | MAP3K5 (0.38) | MAP3K5ABL1RIPK2 | |
| SCHEMBL28657017 | 0.85 | MAP3K5 (0.40) | MAP3K5ABL1RIPK2 | |
| SCHEMBL28928037 | 0.84 | MAP3K5 (0.42) | MAP3K5HCAR1P2RY14ABL1RIPK2 | |
| SCHEMBL27959304 | 0.80 | MAP3K5 (0.52) | MAP3K5DDB1CRBN | |
| SCHEMBL27913610 | 0.76 | HCAR1 (0.39) | TTRHCAR1P2RY14HCAR2 | |
| SCHEMBL233897 | 0.75 | MAP3K5 (0.44) | TTRMAP3K5 | |
| SCHEMBL20672223 | 0.75 | MAP3K5 (0.42) | MAP3K5RIPK2 | |
| SCHEMBL30029659 | 0.75 | MAP3K5 (0.42) | MAP3K5RIPK2 | |
| SCHEMBL27959287 | 0.75 | KMO (0.49) | MAP3K5KDM4C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-109400625-B | Fused bicyclic compound and application thereof in medicine | 广东东阳光药业有限公司 | 2021-11-12 | — | — | CN | disclosed |