Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.60 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.58 |
| ▸ | RAB9A | P51151 | 3/20 | 0.58 |
| ▸ | GAA | P10253 | 2/20 | 0.58 |
| ▸ | CDC7 | O00311 | 2/20 | 0.58 |
| ▸ | DBF4 | Q9UBU7 | 2/20 | 0.58 |
| ▸ | NPC1 | O15118 | 1/20 | 0.56 |
| ▸ | POLB | P06746 | 1/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.53 |
| ▸ | TARBP2 | Q15633 | 2/20 | 0.50 |
| ▸ | GSK3B | P49841 | 1/20 | 0.50 |
| ▸ | XDH | P47989 | 4/20 | 0.47 |
| ▸ | ABCC4 | O15439 | 1/20 | 0.47 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.47 |
| ▸ | PGR | P06401 | 1/20 | 0.47 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.47 |
| ▸ | PDE4A | P27815 | 1/20 | 0.47 |
| ▸ | BLVRB | P30043 | 1/20 | 0.47 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28658387 | 0.85 | SMN1; SMN2 (0.58) | SMN1; SMN2KDM4ERAB9AGAACDC7 | |
| SCHEMBL28654454 | 0.83 | CDC7 (0.57) | SMN1; SMN2KDM4ERAB9AGAACDC7 | |
| SCHEMBL27875453 | 0.81 | CDC7 (0.63) | SMN1; SMN2KDM4ERAB9AGAACDC7 | |
| SCHEMBL28660397 | 0.80 | SMN1; SMN2 (0.56) | SMN1; SMN2KDM4ERAB9AGAANPC1 | |
| SCHEMBL3328924 | 0.79 | SMN1; SMN2 (0.76) | SMN1; SMN2KDM4ERAB9AGAACDC7 | |
| SCHEMBL12582103 | 0.79 | SMN1; SMN2 (0.70) | SMN1; SMN2KDM4ERAB9AGAANPC1 | |
| SCHEMBL28656962 | 0.79 | KDM4E (0.52) | SMN1; SMN2KDM4ERAB9AGAACDC7 | |
| SCHEMBL14018508 | 0.78 | RAB9A (0.77) | SMN1; SMN2KDM4ERAB9AGAANPC1 | |
| SCHEMBL21156699 | 0.77 | RAB9A (0.69) | SMN1; SMN2KDM4ERAB9AGAANPC1 | |
| SCHEMBL623016 | 0.76 | CDC7 (0.51) | SMN1; SMN2RAB9AGAACDC7DBF4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-113024534-A | 2-pyridylthiazole derivatives and use thereof | 武汉光谷亚太医药研究院有限公司 | 2021-06-25 | — | — | CN | claimed |
| CN-113024534-B | 2-pyridylthiazole derivatives and use thereof | 武汉光谷亚太医药研究院有限公司 | 2023-03-21 | — | — | CN | disclosed |
| CN-113024534-A | 2-pyridylthiazole derivatives and use thereof | 武汉光谷亚太医药研究院有限公司 | 2021-06-25 | — | — | CN | disclosed |