Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | AR | P10275 | 1/20 | 0.42 |
| ▸ | KDR | P35968 | 4/20 | 0.42 |
| ▸ | BRAF | P15056 | 3/20 | 0.42 |
| ▸ | SYK | P43405 | 4/20 | 0.41 |
| ▸ | TNIK | Q9UKE5 | 1/20 | 0.41 |
| ▸ | CDK4 | P11802 | 2/20 | 0.40 |
| ▸ | CDK2 | P24941 | 2/20 | 0.40 |
| ▸ | CLK2 | P49760 | 1/20 | 0.40 |
| ▸ | IRAK1 | P51617 | 1/20 | 0.40 |
| ▸ | NEK4 | P51957 | 1/20 | 0.40 |
| ▸ | MAP4K2 | Q12851 | 1/20 | 0.40 |
| ▸ | HIPK4 | Q8NE63 | 1/20 | 0.40 |
| ▸ | SRPK1 | Q96SB4 | 1/20 | 0.40 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.40 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.40 |
| ▸ | MAP3K20 | Q9NYL2 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20577943 | 0.84 | RXFP1 (0.47) | RXFP1KDRBRAFSYKHIPK4 | |
| SCHEMBL28679540 | 0.79 | TAS2R14 (0.46) | RXFP1KDRSYKCDK2CLK2 | |
| SCHEMBL29448791 | 0.77 | RXFP1 (0.55) | RXFP1KDR | |
| SCHEMBL20578118 | 0.76 | RXFP1 (0.60) | RXFP1ALDH1A1KDRBRAFMAPT | |
| SCHEMBL20578021 | 0.76 | LMNA (0.46) | ALDH1A1BRAF | |
| SCHEMBL20577956 | 0.76 | RXFP1 (0.48) | RXFP1KDRBRAFPOLB | |
| SCHEMBL28175979 | 0.75 | RXFP1 (0.54) | RXFP1KDRAURKBPOLBMAPT | |
| SCHEMBL20577759 | 0.75 | RXFP1 (0.44) | RXFP1KDRBRAFSYKAURKB | |
| SCHEMBL20577777 | 0.74 | RXFP1 (0.53) | RXFP1KDR | |
| SCHEMBL20578150 | 0.74 | RXFP1 (0.53) | RXFP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-109071543-B | Pyridine derivatives inhibiting RAF kinase and vascular endothelial growth factor receptor, process for their preparation, pharmaceutical compositions containing them and their use | 三进制药株式会社 | 2021-07-16 | — | — | CN | disclosed |