Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TAS2R14 | Q9NYV8 | 1/20 | 0.46 |
| ▸ | SYK | P43405 | 4/20 | 0.45 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.43 |
| ▸ | RORC | P51449 | 5/20 | 0.42 |
| ▸ | ACVR1 | Q04771 | 8/20 | 0.42 |
| ▸ | GSK3A | P49840 | 4/20 | 0.42 |
| ▸ | GSK3B | P49841 | 4/20 | 0.42 |
| ▸ | CDK8 | P49336 | 4/20 | 0.41 |
| ▸ | FLT3 | P36888 | 3/20 | 0.41 |
| ▸ | RET | P07949 | 3/20 | 0.41 |
| ▸ | RPS6KA3 | P51812 | 2/20 | 0.41 |
| ▸ | FGFR1 | P11362 | 2/20 | 0.41 |
| ▸ | JAK2 | O60674 | 2/20 | 0.41 |
| ▸ | NTRK1 | P04629 | 2/20 | 0.41 |
| ▸ | JAK3 | P52333 | 2/20 | 0.41 |
| ▸ | MAP2K1 | Q02750 | 2/20 | 0.41 |
| ▸ | MET | P08581 | 1/20 | 0.41 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.41 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.41 |
| ▸ | NTRK3 | Q16288 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28665642 | 0.88 | SYK (0.47) | SYKRXFP1RORCCDK1KDR | |
| SCHEMBL20577989 | 0.84 | CBLB (0.50) | RXFP1FLT3IRAK4 | |
| SCHEMBL28664640 | 0.79 | RXFP1 (0.45) | SYKRXFP1GSK3AGSK3BCLK4 | |
| SCHEMBL25255289 | 0.75 | LCK (0.54) | DYRK1A | |
| SCHEMBL31114701 | 0.75 | LCK (0.54) | DYRK1A | |
| SCHEMBL20578118 | 0.74 | RXFP1 (0.60) | RXFP1NTRK1KDR | |
| SCHEMBL20578021 | 0.74 | LMNA (0.46) | RORC | |
| SCHEMBL24393103 | 0.73 | SYK (0.44) | SYKRORCCDK1AURKBMAPKAPK2 | |
| SCHEMBL20577956 | 0.73 | RXFP1 (0.48) | RXFP1RORCKDR | |
| SCHEMBL20577982 | 0.73 | GRM4 (0.42) | SYKRXFP1RORCKDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-109071543-B | Pyridine derivatives inhibiting RAF kinase and vascular endothelial growth factor receptor, process for their preparation, pharmaceutical compositions containing them and their use | 三进制药株式会社 | 2021-07-16 | — | — | CN | disclosed |