Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM5 | P41594 | 2/20 | 0.39 |
| ▸ | TSHR | P16473 | 2/20 | 0.36 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.36 |
| ▸ | ATM | Q13315 | 1/20 | 0.36 |
| ▸ | GPR183 | P32249 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 2/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | USP2 | O75604 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | MMP13 | P45452 | 2/20 | 0.34 |
| ▸ | ADAM17 | P78536 | 2/20 | 0.34 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.34 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.34 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.34 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28649296 | 0.86 | GRM5 (0.40) | GRM5TSHRALOX15ATMMEN1 | |
| SCHEMBL28654152 | 0.77 | GPR119 (0.45) | GRM5TSHRALOX15ATMGPR183 | |
| SCHEMBL25238516 | 0.76 | CYP1A2 (0.36) | GRM5ATMALDH1A1MAPT | |
| SCHEMBL28653404 | 0.75 | USP2 (0.45) | TSHRALOX15ATMUSP2SMN1; SMN2 | |
| SCHEMBL28643218 | 0.75 | GPR119 (0.41) | GPR183GPR119HPGD | |
| SCHEMBL30437960 | 0.75 | GRM5 (0.54) | GRM5GPR183 | |
| SCHEMBL31556485 | 0.73 | MAPT (0.48) | GPR183MAPTMMP13GPR119 | |
| SCHEMBL25799625 | 0.73 | GRM5 (0.53) | GRM5 | |
| SCHEMBL28670704 | 0.72 | USP2 (0.43) | USP2SMN1; SMN2MMP13ADAM17GPR119 | |
| SCHEMBL28646247 | 0.72 | GRM5 (0.57) | GRM5TSHRALOX15ATMALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-113620945-B | RET inhibitor, pharmaceutical composition thereof and application of RET inhibitor in medicines | 广东东阳光药业股份有限公司 | 2024-08-23 | — | — | CN | disclosed |
| CN-113620945-A | RET inhibitor, pharmaceutical composition thereof and application thereof in medicines | 广东东阳光药业有限公司 | 2021-11-09 | — | — | CN | disclosed |