Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | USP2 | O75604 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | MMP13 | P45452 | 5/20 | 0.37 |
| ▸ | ADAM17 | P78536 | 5/20 | 0.37 |
| ▸ | RECQL | P46063 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.35 |
| ▸ | MMP2 | P08253 | 2/20 | 0.35 |
| ▸ | MMP14 | P50281 | 1/20 | 0.35 |
| ▸ | CTSK | P43235 | 1/20 | 0.34 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.34 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.34 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.34 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28675542 | 0.84 | USP2 (0.42) | USP2SMN1; SMN2MMP13ADAM17RECQL | |
| SCHEMBL28653404 | 0.82 | USP2 (0.45) | USP2SMN1; SMN2MMP13ADAM17RECQL | |
| SCHEMBL25799502 | 0.80 | USP2 (0.41) | USP2SMN1; SMN2MMP13ADAM17RECQL | |
| SCHEMBL26666950 | 0.77 | USP2 (0.46) | USP2SMN1; SMN2RECQLHPGDEPHX2 | |
| SCHEMBL16049629 | 0.74 | MMP13 (0.44) | USP2SMN1; SMN2MMP13ADAM17RECQL | |
| SCHEMBL28654152 | 0.73 | GPR119 (0.45) | GPR119 | |
| SCHEMBL16049580 | 0.73 | USP2 (0.39) | USP2SMN1; SMN2MMP13ADAM17RECQL | |
| SCHEMBL25799541 | 0.73 | GPR183 (0.36) | USP2SMN1; SMN2HPGDEPHX2 | |
| SCHEMBL28665690 | 0.72 | GRM5 (0.39) | USP2SMN1; SMN2MMP13ADAM17HPGD | |
| SCHEMBL22983591 | 0.72 | USP2 (0.41) | USP2SMN1; SMN2RECQLHPGDEPHX2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-113620944-B | Novel RET inhibitors, pharmaceutical compositions thereof and uses thereof | 广东东阳光药业股份有限公司 | 2024-10-15 | — | — | CN | disclosed |
| CN-113620944-A | Novel RET inhibitors, pharmaceutical compositions thereof and uses thereof | 广东东阳光药业有限公司 | 2021-11-09 | — | — | CN | disclosed |