SCHEMBL2866727

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

	Compound	similarity	top predicted	shared targets
	SCHEMBL2864364	0.85	DRD2 (0.40)	JAK2JAK3SMN1; SMN2DRD2DRD4
	SCHEMBL2865454	0.83	JAK2 (0.41)	JAK2JAK3DRD2DRD4SIRT2
	SCHEMBL4155857	0.72	PDE4B (0.38)	HTTL3MBTL1SMN1; SMN2DRD2DRD4
	SCHEMBL2864599	0.71	SLC6A3 (0.39)	JAK2JAK3SLC6A3
	SCHEMBL4136502	0.71	HTR4 (0.33)	JAK2DRD2DRD4MEN1KMT2A
	SCHEMBL4152330	0.70	TUBB1 (0.40)	DRD2DRD4
	SCHEMBL4153493	0.70	HTR4 (0.35)	L3MBTL1DRD2DRD4MEN1KMT2A
	SCHEMBL4144664	0.70	DRD2 (0.33)	DRD2DRD4MEN1KMT2A
	SCHEMBL4157519	0.70	GPR183 (0.35)	RAB9ANPC1
	SCHEMBL4334570	0.69	KDM4E (0.39)	JAK2JAK3HTTL3MBTL1POLB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.