SCHEMBL28669752

SCHEMBL28669752

COc1cccc(-c2c3ccccc3cc3ccccc23)c1

nearest known ligand 0.60

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALOX5 P09917 2/20 0.60
GPR84 Q9NQS5 1/20 0.57
CYP1A2 P05177 7/20 0.51
CYP2C9 P11712 4/20 0.51
CYP3A4 P08684 3/20 0.51
CYP2B6 P20813 3/20 0.51
AHR P35869 3/20 0.51
NR1I3 Q14994 3/20 0.51
VDR P11473 2/20 0.51
ADORA2A P29274 1/20 0.50
CYP1A1 P04798 2/20 0.48
CYP1B1 Q16678 2/20 0.48
CYP2D6 P10635 2/20 0.48
CLK4 Q9HAZ1 2/20 0.48
NR1I2 O75469 1/20 0.48
ALDH1A1 P00352 1/20 0.48
F2 P00734 1/20 0.48
HPGD P15428 1/20 0.48
KMT2A Q03164 1/20 0.48
USP2 O75604 1/20 0.48

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL27862687 0.84 CYP1A2 (0.60) ALOX5GPR84CYP1A2CYP2C9CYP3A4
SCHEMBL10013792 0.83 ALOX5 (0.52) ALOX5GPR84CYP1A2CYP2C9CYP3A4
SCHEMBL29587463 0.83 CYP1A2 (0.64) CYP1A2CYP2C9CYP3A4CYP2B6AHR
SCHEMBL601233 0.83 CYP1A2 (0.64) CYP1A2CYP2C9CYP3A4CYP2B6AHR
SCHEMBL31411912 0.82 KMT2A (0.51) ALOX5GPR84CYP1A2CYP2C9CYP3A4
SCHEMBL12583245 0.82 GPR84 (0.61) ALOX5GPR84CYP1A2CYP2C9CYP3A4
SCHEMBL21615639 0.82 GPR84 (0.61) ALOX5GPR84CYP1A2CYP2C9CYP3A4
SCHEMBL18762062 0.81 ALOX5 (0.58) ALOX5GPR84CYP1A2CYP2C9CYP3A4
SCHEMBL29847407 0.81 ALOX5 (0.58) ALOX5GPR84CYP1A2CYP2C9CYP3A4
SCHEMBL15366516 0.81 CYP1A2 (0.61) ALOX5GPR84CYP1A2CYP2C9CYP3A4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-113860984-A Magnesium-activated ligand-promoted chromium-catalyzed polycyclic aromatic hydrocarbon and olefin regioselective hydrogenation method 延安大学 2021-12-31 CN disclosed
CN-107216229-A A kind of method of chromic salts/methyl-magnesium-bromide selective catalytic hydrogenation polycyclic aromatic hydrocarbon 四川大学 2017-09-29 CN disclosed