Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CES2 | O00748 | 1/20 | 0.59 |
| ▸ | MAPT | P10636 | 2/20 | 0.58 |
| ▸ | POLB | P06746 | 1/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.56 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.56 |
| ▸ | GPR35 | Q9HC97 | 2/20 | 0.56 |
| ▸ | TP53 | P04637 | 1/20 | 0.56 |
| ▸ | HPGD | P15428 | 1/20 | 0.56 |
| ▸ | TSHR | P16473 | 1/20 | 0.56 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.53 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.52 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.51 |
| ▸ | CA12 | O43570 | 1/20 | 0.51 |
| ▸ | CA9 | Q16790 | 1/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.50 |
| ▸ | MEN1 | O00255 | 3/20 | 0.50 |
| ▸ | TXNRD1 | Q16881 | 1/20 | 0.50 |
| ▸ | TXNRD3 | Q86VQ6 | 1/20 | 0.50 |
| ▸ | TXNRD2 | Q9NNW7 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13010942 | 0.85 | GPR35 (0.56) | CES2MAPTPOLBALDH1A1SMN1; SMN2 | |
| SCHEMBL3656114 | 0.85 | MAPK1 (0.57) | CES2MAPTALDH1A1SMN1; SMN2MAPK1 | |
| SCHEMBL5341177 | 0.85 | CES2 (0.63) | CES2MAPTPOLBALDH1A1SMN1; SMN2 | |
| SCHEMBL503450 | 0.83 | CES2 (0.66) | CES2MAPTPOLBALDH1A1SMN1; SMN2 | |
| SCHEMBL9692669 | 0.83 | CES2 (0.61) | CES2MAPTPOLBALDH1A1SMN1; SMN2 | |
| SCHEMBL28843843 | 0.83 | MAPT (0.50) | CES2MAPTPOLBALDH1A1MAPK1 | |
| Methylamine SCHEMBL9861803 | 0.82 | ALDH1A1 (0.65) | CES2MAPTPOLBALDH1A1SMN1; SMN2 | |
| SCHEMBL8489269 | 0.82 | CES2 (0.52) | CES2MAPTPOLBALDH1A1SMN1; SMN2 | |
| Benzene SCHEMBL10436419 | 0.81 | CES2 (0.69) | CES2MAPTPOLBALDH1A1SMN1; SMN2 | |
| SCHEMBL2327506 | 0.81 | BACE1 (0.45) | CES2MAPTALDH1A1MAPK1GPR35 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 21 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-117924177-A | Preparation method of pazopanib intermediate 2, 3-dimethyl-6-amino-2H-indazole and analogues thereof | 南京杰运医药科技有限公司 | 2024-04-26 | — | — | CN | disclosed |
| EP-3246308-A1 | METHOD FOR PRODUCING AROMATIC AMINE COMPOUND | Nissan Chemical Industries, Ltd. (JP) | 2017-11-22 | — | — | EP | disclosed |
| US-7842701-B2 | Pyrazoloquinolone derivative and use thereof | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2010-11-30 | — | — | US | disclosed |
| US-7541339-B2 | Par-2-activating peptide derivative and pharmaceutical composition using the same | THE UNIVERSITY OF EDINBURGH (GB) | 2009-06-02 | — | — | US | disclosed |
| US-20070281963-A1 | Pyrazoloquinolone Derivative And Use Thereof | TAKEDA PHARMACEUTICAL COMPANY (JP) | 2007-12-06 | — | — | US | disclosed |
| EP-1719771-A1 | PYRAZOLOQUINOLONE DERIVATIVE AND USE THEREOF | Takeda Pharmaceutical Company Limited (JP) | 2006-11-08 | — | — | EP | disclosed |
| CN-1246292-C | Disproportionation of nitro aromatic compounds | UNIV TSINGHUA (CN) | 2006-03-22 | — | — | CN | disclosed |
| CN-1490301-A | Disproportionation of nitro aromatic compounds | 清华大学 | 2004-04-21 | — | — | CN | disclosed |
| EP-0114482-B1 | A PHOTOSENSITIVE COMPOSITION FOR ELECTROPHOTOGRAPHY | MITA INDUSTRIAL CO. LTD. (JP) | 1988-09-14 | — | — | EP | disclosed |
| US-4741981-A | Photosensitive material for electrophotography contains organic phosphite compounds | RICOH CO., LTD. (JP) | 1988-05-03 | — | — | US | disclosed |
| US-4574114-A | Photosensitive composition for electrophotography having polyvinyl carbazole and silicone oil | MITA INDUSTRIAL COMPANY, LTD. (JP) | 1986-03-04 | — | — | US | disclosed |
| US-4521504-A | DICHROMATIC IMAGES-CONDUCTIVE SUBSTRATE LAMINATED WITH PHOTOCONDUCTIVE | RICOH COMPANY, LTD. (JP) | 1985-06-04 | — | — | US | disclosed |
| US-4469769-A | Photosensitive material for electrophotography contains halo-benzoquinone sensitizer | MITA INDUSTRIAL CO. LTD. (JP) | 1984-09-04 | — | — | US | disclosed |
| EP-0100581-A2 | Photosensitive material for electrophotography | MITA INDUSTRIAL CO. LTD. (JP) | 1984-02-15 | — | — | EP | disclosed |
| US-4370398-A | Electrostatic copying process | RICOH COMPANY, LTD. (JP) | 1983-01-25 | — | — | US | disclosed |
| US-4361638-A | AMORPHOUS SILICON AND CARBON BASE MATERIAL DOPED WITH HYDROGEN AND FLUORINE | FUJI PHOTO FILM CO., LTD. (JP) | 1982-11-30 | — | — | US | disclosed |
| US-4352942-A | TREATMENT OF ISOMERIC MIXTURE OF NITRO AROMATIC KETO COMPOUNDS WITH OLEUM | GULF RESEARCH & DEVELOPMENT COMPANY (US) | 1982-10-05 | — | — | US | disclosed |
| US-4214094-A | ANTILIPEMIC AGENTS | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1980-07-22 | — | — | US | disclosed |
| US-4159372-A | Process for preparing cephalosporin esters in the presence of liquid sulfur dioxide | MEIJI SEIKA KAISHA LTD. (JP) | 1979-06-26 | — | — | US | disclosed |
| US-3971825-A | (5,6) (10,11) BIS-METHYLENE, BRONCHODILATORS | SANKYO COMPANY LIMITED (JA) | 1976-07-27 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070281963-A1 | Pyrazoloquinolone Derivative And Use Thereof | MAP3K20, MAP4K5, MAP4K3 | CES2 3836/4885MAPT 4583/4885POLB 4153/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.