Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NTRK1 | P04629 | 16/20 | 0.46 |
| ▸ | JAK2 | O60674 | 13/20 | 0.46 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28670737 | 1.00 | NTRK1 (0.46) | NTRK1JAK2RIPK1 | |
| SCHEMBL949026 | 0.77 | NTRK1 (0.48) | NTRK1JAK2 | |
| SCHEMBL15017388 | 0.74 | NTRK1 (0.46) | NTRK1JAK2 | |
| SCHEMBL17848931 | 0.69 | NTRK1 (0.45) | NTRK1JAK2 | |
| SCHEMBL4301475 | 0.67 | RIPK1 (0.43) | NTRK1JAK2RIPK1 | |
| SCHEMBL27619913 | 0.67 | RIPK1 (0.43) | NTRK1JAK2RIPK1 | |
| SCHEMBL1538366 | 0.65 | CHRNB4 (0.62) | — | |
| SCHEMBL1538368 | 0.65 | CHRNB4 (0.62) | — | |
| SCHEMBL29422913 | 0.65 | CHRNB4 (0.62) | — | |
| SCHEMBL4106227 | 0.64 | RIPK1 (0.43) | NTRK1JAK2RIPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-110003214-B | Substituted pyrazolo [1,5-a ] pyrimidine compounds as TRK kinase inhibitors | 阵列生物制药公司 | 2021-12-21 | — | — | CN | disclosed |