Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NTRK1 | P04629 | 15/20 | 0.45 |
| ▸ | JAK2 | O60674 | 14/20 | 0.45 |
| ▸ | NUDT1 | P36639 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3769485 | 0.84 | NTRK1 (0.49) | NTRK1JAK2NUDT1 | |
| SCHEMBL983254 | 0.77 | NTRK1 (0.48) | NTRK1JAK2 | |
| SCHEMBL988331 | 0.77 | NTRK1 (0.48) | NTRK1JAK2 | |
| SCHEMBL27095477 | 0.76 | PIK3C3 (0.48) | NTRK1JAK2 | |
| SCHEMBL28173612 | 0.76 | PIK3C3 (0.48) | NTRK1JAK2 | |
| SCHEMBL26968000 | 0.76 | PIK3C3 (0.48) | NTRK1JAK2 | |
| SCHEMBL979031 | 0.75 | NTRK1 (0.49) | NTRK1JAK2 | |
| SCHEMBL981114 | 0.75 | NTRK1 (0.49) | NTRK1JAK2 | |
| SCHEMBL21097295 | 0.74 | NTRK1 (0.43) | NTRK1 | |
| SCHEMBL28918152 | 0.74 | NTRK1 (0.43) | NTRK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3233863-A1 | FUSED RING HETEROARYL COMPOUNDS AND THEIR USE AS TRK INHIBITORS | CMG Pharmaceutical Co., Ltd. (KR) | 2017-10-25 | — | — | EP | disclosed |
| WO-2016097869-A1 | FUSED RING HETEROARYL COMPOUNDS AND THEIR USE AS TRK INHIBITORS | CMG PHARMACEUTICAL CO., LTD. (KR) | 2016-06-23 | — | — | WO | disclosed |