Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RIPK1 | Q13546 | 2/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
| ▸ | CHRNB2 | P17787 | 4/20 | 0.34 |
| ▸ | CHRNA4 | P43681 | 4/20 | 0.34 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.34 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.34 |
| ▸ | MAOA | P21397 | 1/20 | 0.34 |
| ▸ | MAOB | P27338 | 1/20 | 0.34 |
| ▸ | JAK2 | O60674 | 1/20 | 0.34 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.34 |
| ▸ | PDE5A | O76074 | 1/20 | 0.34 |
| ▸ | DPP4 | P27487 | 1/20 | 0.34 |
| ▸ | NR3C2 | P08235 | 1/20 | 0.34 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.34 |
| ▸ | PIK3R1 | P27986 | 1/20 | 0.34 |
| ▸ | SLC6A9 | P48067 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL455586 | 0.79 | RIPK1 (0.40) | RIPK1MAOAMAOBJAK2NTRK1 | |
| SCHEMBL981085 | 0.74 | RIPK1 (0.34) | RIPK1MAOAMAOBJAK2NTRK1 | |
| SCHEMBL448624 | 0.73 | RIPK1 (0.47) | RIPK1MAOAMAOBJAK2NTRK1 | |
| SCHEMBL430776 | 0.73 | RIPK1 (0.47) | RIPK1MAOAMAOBJAK2NTRK1 | |
| SCHEMBL945868 | 0.69 | NTRK1 (0.58) | JAK2NTRK1 | |
| SCHEMBL4518142 | 0.67 | RIPK1 (0.41) | RIPK1MAOAMAOBPDE5A | |
| SCHEMBL4501581 | 0.67 | RIPK1 (0.41) | RIPK1MAOAMAOBPDE5A | |
| SCHEMBL433152 | 0.67 | HTR2A (0.35) | RIPK1MAOAMAOB | |
| SCHEMBL431587 | 0.67 | HTR2A (0.35) | RIPK1MAOAMAOB | |
| SCHEMBL451170 | 0.67 | HTR2A (0.35) | RIPK1MAOAMAOB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-110003214-B | Substituted pyrazolo [1,5-a ] pyrimidine compounds as TRK kinase inhibitors | 阵列生物制药公司 | 2021-12-21 | — | — | CN | disclosed |